# US 9,433,784 B2 · Systems and methods for treating dyspnea, including via electrical afferent signal blocking

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 9,433,784 B2
- Document ID: US9433784B2
- Status: Granted
- Kind: B2
- Application number: 14/811,581
- Filed: 2015-07-28
- Published: 2015-11-19
- Granted: 2016-09-06
- Earliest claimed: 2008-08-11
- Assignees: Cibiem, Inc.
- Applicants: Cibiem, Inc.
- Inventors: Edwin J. Hlavka; Lynn S. Elliott
- Web page: https://patentgrep.com/patent/US9433784B2

## CPC

- A61N 1/3601: {of respiratory organs}
- A61N 1/0556: {Cuff electrodes}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Systems and methods for treating a patient with dyspnea are disclosed. A method in accordance with a particular embodiment includes identifying the patient as suffering from dyspnea, and, based at least in part on identifying the patient as suffering from dyspnea, implanting an electrical signal delivery element within the patient in signal communication with an afferent neural pathway of a carotid body chemoreceptor. The method can further include at least reducing dyspneic sensations in the patient by directing an electrical signal from the electrical signal delivery element to the neural pathway to at least partially block afferent signals from the chemoreceptor.

## Claims

### Claim 1

A method for treating a patient comprising:
delivering an electrical signal from a controller to a signal delivery device;
directing a neural blocking signal from the signal delivery device to a carotid body in a human patient to block afferent signals from the carotid body, wherein directing the neural blocking signal to the carotid body does not direct the neural blocking signal to a carotid baroreceptor neuron, and
wherein blocking the afferent signals achieves a therapeutic effect by disabling a function of the carotid body in sensing hypoxia or hypercapnia.

### Claim 2 (depends on 1)

The method of claim 1 wherein directing the neural blocking signal is in response to receiving an input.

### Claim 3 (depends on 1)

The method of claim 1 further comprising implanting the signal delivery device within the patient in signal communication with the carotid body.

### Claim 4 (depends on 1)

The method of claim 1 further comprising orienting the signal delivery device to direct the neural blocking signal from the signal delivery device to the carotid body.

### Claim 5 (depends on 1)

The method of claim 1 wherein, prior to directing the neural blocking signal, simulating carotid body inhibition.

### Claim 6

A method for treating a patient comprising:
delivering an electrical signal from a controller to a signal delivery device;
directing a neural blocking signal from the signal delivery device to a carotid body in a human patient to block afferent signals from the carotid body; and
positioning the signal delivery device with respect to the carotid body such that blocking the afferent signals from the carotid body with the neural blocking signal does not interfere with afferent signals transmitted by baroreceptor neurons in the patient,
wherein blocking the afferent signals achieves a therapeutic effect by disabling a function of the carotid body in sensing hypoxia or hypercapnia.

### Claim 7 (depends on 6)

The method of claim 6 wherein directing the neural blocking signal is in response to receiving an input.

### Claim 8 (depends on 6)

The method of claim 6 further comprising implanting the signal delivery device within the patient in signal communication with the carotid body.

### Claim 9 (depends on 6)

The method of claim 6 further comprising orienting the signal delivery device to direct the neural blocking signal from the signal delivery device to the carotid body.

### Claim 10 (depends on 6)

The method of claim 6 wherein, prior to directing the neural blocking signal, simulating carotid body inhibition.