# US 9,433,761 B2 · Microvascular obstruction detection and therapy

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- Number: US 9,433,761 B2
- Document ID: US9433761B2
- Status: Granted
- Kind: B2
- Application number: 13/759,431
- Filed: 2013-02-05
- Published: 2013-06-13
- Granted: 2016-09-06
- Earliest claimed: 2006-08-02
- Assignees: Osprey Medical, Inc.
- Applicants: Osprey Medical, Inc.
- Inventors: Robert S. Schwartz; Robert A. Van Tassel
- Web page: https://patentgrep.com/patent/US9433761B2

## CPC

- A61M 25/007: {Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked}
- A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance}
- A61B 5/0215: by means inserted into the body
- A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
- A61B 8/00: Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B 8/06: Measuring blood flow
- A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00})
- A61M 25/1011: {Multiple balloon catheters}
- A61M 37/0092: {using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis}
- A61M 2025/0002: {with a pressure sensor at the distal end}
- A61M 2025/0003: {having an additional lumen transmitting fluid pressure to the outside for measurement}
- A61M 2025/1052: {for temporarily occluding a vessel for isolating a sector}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method of detecting and treating a microvascular obstruction is provided. In one embodiment, a catheter is provided for both detecting the microvascular obstruction and treating or removing the obstruction.

## Claims

### Claim 1

A method for treating an obstruction of a microvascular vessel within a patient, comprising:
advancing a distal end of a guidewire to a location in communication with said obstruction;
advancing a distal end of a treatment catheter over said guidewire to said location in communication with said obstruction;
releasing a treatment agent from said treatment catheter;
monitoring an impedance of said microvascular vessel, wherein the impedance is based on at least one of, in part, a pressure, a flow volume, a flow direction, and a flow velocity;
stopping said releasing of said treatment agent when said impedance indicates removal of said obstruction.

### Claim 2 (depends on 1)

The method of claim 1, wherein said monitoring an impedance of said microvascular vessel comprises determining an impedance by dividing a flow measurement of said treatment agent by a pressure measurement of a location in communication with said microvascular vessel.

### Claim 3 (depends on 2)

The method of claim 2, wherein said flow measurement comprises measuring a pressure differential between a fixed resistance in communication with said microvascular vessel.

### Claim 4 (depends on 3)

The method of claim 3, wherein said pressure measurement of a location in communication with said microvascular vessel is measured with a pressure transducer coupled to said treatment catheter.

### Claim 5 (depends on 1)

The method of claim 1, further comprising exposing said obstruction to ultrasonic energy.

### Claim 6 (depends on 1)

The method of claim 1, further comprising expanding an occlusion member.

### Claim 7 (depends on 6)

The method of claim 6, wherein expanding the occlusion member includes inflating a first balloon proximate a treatment agent port on the treatment catheter.

### Claim 8 (depends on 7)

The method of claim 7, wherein expanding the occlusion member further includes inflating a second balloon disposed on an opposite side of the treatment agent port from the first balloon.

### Claim 9 (depends on 8)

The method of claim 8, wherein monitoring is performed from a location disposed between the first balloon and the second balloon.

### Claim 10 (depends on 1)

The method of claim 1, wherein the impedance has a phasic characteristic.

### Claim 11 (depends on 1)

The method of claim 1, wherein at least one of the pressure, the flow volume, the flow direction, and the flow velocity are a measurement of blood within the microvascular vessel.