# US 9,433,748 B2 · Bio-compatible catheter > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,748 B2 - Document ID: US9433748B2 - Status: Granted - Kind: B2 - Application number: 14/599,944 - Filed: 2015-01-19 - Published: 2015-05-14 - Granted: 2016-09-06 - Earliest claimed: 2011-08-26 - Assignees: Pfm Medical AG - Applicants: PFM Medical, Inc. - Inventors: Marshall Kerr - Web page: https://patentgrep.com/patent/US9433748B2 ## CPC - A61M 25/0045: {multi-layered, e.g. coated (coating materials A61L29/08)} - A61L 29/106: {Inorganic materials other than carbon} - A61L 29/14: Materials characterised by their function or physical properties {, e.g. lubricating compositions} - A61L 29/16: Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} - A61L 33/027: {Other specific inorganic materials not covered by A61L33/022 or A61L33/025} - A61M 1/285: {Catheters therefor} - A61M 1/3661: {for haemodialysis} - A61M 25/0017: {specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections} - A61M 27/002: {Implant devices for drainage of body fluids from one part of the body to another (intraocular A61F9/00781; middle ear A61F11/202)} - A61M 27/006: {Cerebrospinal drainage; Accessories therefor, e.g. valves} - A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/42: Anti-thrombotic agents, anticoagulants, anti-platelet agents - A61L 2400/10: Materials for lubricating medical devices - A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment - A61M 2025/0046: {Coatings for improving slidability} - A61M 2205/0222: Materials for reducing friction - A61M 2210/1017: Peritoneal cavity - A61M 2210/12: Blood circulatory system - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract A bio-compatible lumen bearing device such as a catheter formed of a polymeric material having a titanium surface bonded to the underlying exposed catheter surface. The titanium surface is employed in patients to improve bio-compatibility and enhance lubricity during insertion and removal. ## Claims ### Claim 1 A lumen bearing component comprising: a lumen defined by an interior surface of a surrounding wall having an exterior surface and additionally having end wall surfaces communicating between said interior surface and said exterior surface, said lumen formed of polymeric material being flexible as needed for intravenous insertion and navigation; a titaniumized surface, said titaniumized surface formed in a first layer completely covering all of said exterior surface of said surrounding wall; said titaniumized surface providing means for increased lubricity and bio-compatibility with a body of a patient in which said catheter is positioned; said titaniumized surface in said first layer being the only surface formed completely on all of said exterior surface, said titaniumized surface being composed exclusively of titanium; a second layer of said titaniumized surface also completely covering all of said interior surface; said titaniumized surface covering said exterior surface in said first layer and said titaniumized surface covering said interior surface in said second layer, both having a thickness, said thickness being substantially being in a range between 20-60 nm; and said thickness of both said first layer and said second layer of said titaniumized surface, within said range, providing means for maintaining a flexibility of the underlying polymeric material. ### Claim 2 (depends on 1) The lumen bearing component of claim 1 wherein said lumen bearing component is a catheter from a group of lumen bearing catheters including Peritoneal Dialysis Catheters, Hemodialysis Catheters, Pleural Drainage Catheters, Peritoneal Drainage Catheters, Biliary Catheters, Urethral Catheters, CV Catheters, Ventricular-Peritoneal Shunts, Ventricular Drainage Catheters, Ascites Shunts, Urinary Catheters, and PICC lines. ### Claim 3 (depends on 1) The lumen bearing component of claim 1, wherein the lumen bearing component is a catheter for communicating with blood vessels of a patient. ### Claim 4 (depends on 3) The lumen bearing component of claim 3 wherein: said titaniumized surface forming a complete barrier to communication between said body of said patient and said polymeric material, thereby preventing blood clot formation, infection, and allergic reactions in said patient such communication can cause. ### Claim 5 (depends on 4) The lumen bearing component of claim 4 wherein: said thickness of said titaniumized surface being maintained in said range through application thereof by covalent bonding to said polymeric material. ### Claim 6 A lumen bearing component comprising: a lumen defined by an interior surface of a surrounding wall having an exterior surface and additionally having end wall surfaces communicating between said interior surface and said exterior surface, said lumen formed of polymeric material being flexible as needed for intravenous insertion and navigation; a titaniumized surface, said titaniumized surface formed in a first layer completely covering all of said exterior surface of said surrounding wall; said titaniumized surface providing means for increased lubricity and bio-compatibility with a body of a patient in which said catheter is positioned; said titaniumized surface in said first layer being the only surface formed completely upon all of said exterior surface, and said titaniumized surface being composed exclusively of titanium; a second layer of said titaniumized surface also completely covering all of said interior surface; said titaniumized surface completely covering all of said end wall surfaces; said titaniumized surface covering said exterior surface in said first layer and said titaniumized surface covering said interior surface in said second layer, both having a thickness, said thickness substantially being in a range between 20-60 nm; and said thickness of both said first layer and said second layer of said titaniumized surface within said range, providing means for maintaining a flexibility of the underlying polymeric material. ### Claim 7 (depends on 6) The lumen bearing component of claim 6, wherein the lumen bearing component is a catheter for communicating with blood vessels of a patient. ### Claim 8 (depends on 7) The lumen bearing component of claim 7 wherein: said titaniumized surface forming a complete barrier to communication between said body of said patient and said polymeric material, thereby preventing blood clot formation, infection, and allergic reactions in said patient such communication can cause. ### Claim 9 (depends on 8) The lumen bearing component of claim 8 wherein: said thickness of said titaniumized surface being maintained in said range through application thereof by covalent bonding to said polymeric material.