# US 9,433,704 B2 · Osteostimulative settable bone graft putty > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,704 B2 - Document ID: US9433704B2 - Status: Granted - Kind: B2 - Application number: 12/074,820 - Filed: 2008-03-06 - Published: 2008-09-11 - Granted: 2016-09-06 - Earliest claimed: 2007-03-09 - Assignees: Novabone Products, LLC - Applicants: Jipin Zhong; David M. Gaisser - Inventors: Jipin Zhong; David M. Gaisser - Web page: https://patentgrep.com/patent/US9433704B2 ## CPC - A61L 27/427: {of other specific inorganic materials not covered by A61L27/422 or A61L27/425} - A61F 2/4644: {Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material (bone material A61F2/28; disintegrating or milling devices B02C)} - A61F 2002/2835: {Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material} - A61F 2002/30032: {differing in absorbability or resorbability, i.e. in absorption or resorption time} - A61F 2002/30062: {(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive} - A61F 2002/30327: {differing in diameter} - A61F 2210/0004: bioabsorbable - A61F 2250/003: differing in adsorbability or resorbability, i.e. in adsorption or resorption time - A61F 2250/0039: differing in diameter - A61F 2310/00329: Glasses, e.g. bioglass - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract A settable osteostimulative bone graft putty composition having a bioactive glass particulate component composed of a long-term and a short-term component; the long-term component having particle sizes greater than 90 micrometers and the short-term component having particle sizes less than 90 micrometers; the long-term component comprising about 60% to 90% of the bioactive glass osteostimulative particulate component dry weight and the short-term component comprising about 40% to 10%; a binder component having a calcium sulfate component and a calcium silicate component; the calcium sulfate component comprising about 35% to 50% of the binder component dry weight and the calcium silicate component comprising about 65% to 50%; the bioactive glass osteostimulative particulate component being about 20% to 60% of the total putty dry weight composition and the binder being about 80% to 40%; the bioactive glass particulate component and the binder component mixable in water to form the putty. ## Claims ### Claim 1 A settable osteostimulative bone graft putty composition consisting essentially of: a bioactive glass osteostimulative particulate component consisting essentially of a long-term bioactive glass osteostimulative particulate component characterized by a slow absorption rate in the human body and a short-term bioactive glass osteostimulative particulate component characterized by a faster absorption rate in the human body than said long-term bioactive glass osteostimulative particulate component; said long-term component having particle sizes greater than 90 micrometers and said short-term component having particle sizes of less than 90 micrometers; said long-term component comprising about 60% to 90% of said bioactive glass osteostimulative particulate component dry weight and said short-term component comprising about 40% to 10% of said bioactive glass osteostimulative particulate component dry weight; a binder component consisting essentially of a calcium sulfate component characterized by a fast setting time and a calcium silicate component characterized by a slower setting time in comparison to said calcium sulfate component; and water; said bioactive glass osteostimulative particulate component and said binder component mixable in said water to form said putty, said putty retaining shape and supporting physiologic loading of up to 40 MPa after setting. ### Claim 2 (depends on 1) The composition of claim 1, said long-term component having particle sizes of between about 120 to 710 micrometers and said short-term component having particle sizes of between about 20 to 50 micrometers. ### Claim 3 (depends on 1) The composition of claim 1, said bioactive glass osteostimulative particulate component comprising about 20% to 60% of the total putty dry weight composition and said binder component comprising about 80% to 40% of the total putty dry weight composition. ### Claim 4 (depends on 3) The composition of claim 3, said bioactive glass osteostimulative particulate component comprising about 20% to 40% of the total putty dry weight composition and said binder component comprising about 80% to 60% of the total putty dry weight composition. ### Claim 5 (depends on 4) The composition of claim 4, said bioactive glass osteostimulative particulate component comprising about 25% to 35% of the total putty dry weight composition and said binder component comprising about 75% to 65% of the total putty dry weight composition. ### Claim 6 (depends on 1) The composition of claim 1, said calcium sulfate component comprising about 35% to 50% of said binder component dry weight and said calcium silicate component comprising about 65% to 50% of said binder component dry weight. ### Claim 7 (depends on 1) The composition of claim 1, approximately 50% of said long-term component having particle sizes of between 250 and 450 micrometers. ### Claim 8 A settable osteostimulative bone graft putty composition consisting essentially of: a bioactive glass osteostimulative particulate component consisting essentially of a long-term bioactive glass osteostimulative particulate component and a short-term bioactive glass osteostimulative particulate component; said long-term component having particle sizes of between 90 to 1000 micrometers and said short-term component having particle sizes of less than 90 micrometers; said long-term component comprising about 60% to 90% of said bioactive glass osteostimulative particulate component dry weight and said short-term component comprising about 40% to 10% of said bioactive glass osteostimulative particulate component dry weight; a binder component consisting essentially of a calcium sulfate component and a calcium silicate component; and water; said bioactive glass osteostimulative particulate component and said binder component mixable in said water to form said putty, said putty retaining shape and supporting physiologic loading of up to 40 MPa after setting. ### Claim 9 (depends on 8) The composition of claim 8, said calcium sulfate component comprising about 35% to 50% of said binder component dry weight and said calcium silicate component comprising about 65% to 50% of said binder component dry weight. ### Claim 10 (depends on 9) The composition of claim 9, said bioactive glass osteostimulative particulate component comprising about 20% to 60% of the total putty dry weight composition and said binder component comprising about 80% to 40% of the total putty dry weight composition. ### Claim 11 (depends on 10) The composition of claim 10, said bioactive glass osteostimulative particulate component comprising about 20% to 40% of the total putty dry weight composition and said binder component comprising about 80% to 60% of the total putty dry weight composition. ### Claim 12 (depends on 11) The composition of claim 11, said bioactive glass osteostimulative particulate component comprising about 25% to 35% of the total putty dry weight composition and said binder component comprising about 75% to 65% of the total putty dry weight composition. ### Claim 13 (depends on 8) The composition of claim 8, said bioactive glass osteostimulative particulate component comprising about 20% to 60% of the total putty dry weight composition and said binder component comprising about 80% to 40% of the total putty dry weight composition. ### Claim 14 (depends on 8) The composition of claim 8, said long-term component having particle sizes of between about 120 to 710 micrometers and said short-term component having particle sizes of between about 20 to 50 micrometers. ### Claim 15 A settable osteostimulative bone graft putty composition consisting essentially of: a bioactive glass osteostimulative particulate component consisting essentially of a long-term bioactive glass osteostimulative particulate component and a short-term bioactive glass osteostimulative particulate component; said long-term component having particle sizes of between about 120 to 710 micrometers and said short-term component having particle sizes of between about 20 to 50 micrometers; said long-term component comprising about 60% to 90% of said bioactive glass osteostimulative particulate component dry weight and said short-term component comprising about 40% to 10% of said bioactive glass osteostimulative particulate component dry weight; a binder component consisting essentially of a calcium sulfate component and a calcium silicate component; said calcium sulfate component comprising about 35% to 50% of said binder component dry weight and said calcium silicate component comprising about 65% to 50% of said binder component dry weight; said bioactive glass osteostimulative particulate component comprising about 20% to 60% of the total putty dry weight composition and said binder component comprising about 80% to 40% of the total putty dry weight composition; and water; said bioactive glass osteostimulative particulate component and said binder component mixable in said water to form said putty, said putty retaining shape and supporting physiologic loading of up to 40 MPa after setting. ### Claim 16 (depends on 15) The composition of claim 15, said bioactive glass osteostimulative particulate component comprising about 25% to 35% of the total putty dry weight composition and said binder component comprising about 75% to 65% of the total putty dry weight composition. ### Claim 17 (depends on 15) The composition of claim 15, approximately 50% of said long-term component having particle sizes of between 250 and 450 micrometers.