# US 9,433,702 B2 · Cartilage material

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- Number: US 9,433,702 B2
- Document ID: US9433702B2
- Status: Granted
- Kind: B2
- Application number: 13/006,949
- Filed: 2011-01-14
- Published: 2011-05-05
- Granted: 2016-09-06
- Earliest claimed: 2007-05-10
- Assignees: Vivex Biomedical, Inc.
- Applicants: Theodore I. Malinin
- Inventors: Theodore I. Malinin
- Web page: https://patentgrep.com/patent/US9433702B2

## CPC

- A61L 27/3695: {characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this (A61L27/3687, A61L27/3691 take precedence)}
- A61F 2/30756: {Cartilage endoprostheses (A61F2/3603 takes precedence)}
- A61K 35/32: Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
- A61L 27/3612: {Cartilage, synovial fluid}
- A61L 27/3654: {Cartilage, e.g. meniscus}
- A61L 27/3683: {subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61P 19/00: Drugs for skeletal disorders
- A61F 2/3094: {Designing or manufacturing processes}
- A61F 2/30965: {Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping}
- A61F 2002/30764: {Cartilage harvest sites}
- A61F 2002/4495: {having a fabric structure, e.g. made from wires or fibres}
- A61F 2310/00365: Proteins; Polypeptides; Degradation products thereof
- A61L 2430/06: for cartilage reconstruction, e.g. meniscus
- A61L 2430/40: Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.

## Claims

### Claim 1

A method of preparing a cartilage fluff composition made of a cohesive interconnected network of cartilage fibers, the cartilage fluff composition comprising strands and branches of cartilage material, wherein one or more cartilage branches are connected to the strands, wherein the cartilage fluff composition is self-supporting, wherein the cartilage strands have an average length of about 1,200 μm to about 3,000 μm and an average width of about 30 μm to about 140 μum, and wherein the one or more branches have an average width up to about 50 μm, the method comprising shaving, milling, or grinding the cartilage of a cartilage source, wherein the cartilage fluff composition is suitable for administering to a cartilage defect in an animal for regenerating cartilage in the animal, without the use of a matrix, cover, or vehicle.

### Claim 2 (depends on 1)

The method of claim 1, wherein the temperature of the cartilage does not exceed about 50 ° C. during the shaving, milling, or grinding.

### Claim 3 (depends on 1)

The method of claim 1, wherein the cartilage is not chemically treated prior to the shaving, milling, or grinding.

### Claim 4 (depends on 1)

The method of claim 1, wherein the cartilage is not demineralized prior to the shaving, milling, or grinding.

### Claim 5 (depends on 1)

The method of claim 1, wherein the growth factors within the cartilage source are not altered prior to the shaving, milling, or grinding.

### Claim 6 (depends on 1)

The method of claim 1, wherein the cartilage source comprises a bone with cartilage.

### Claim 7 (depends on 1)

The method of claim 1, wherein the bone with cartilage is secured in a digitizing machine.

### Claim 8 (depends on 1)

The method of claim 1, wherein the cartilage is unattached to bone.

### Claim 9 (depends on 1)

The method of claim 1, wherein the shaving, milling, or grinding is carried out with a drill bit, core drill, or burr.

### Claim 10 (depends on 1)

The method of claim 1, comprising shaving the cartilage.

### Claim 11 (depends on 1)

The method of claim 1, wherein the cartilage material is a fresh cartilage, freeze-dried cartilage, frozen cartilage, or cryo-preserved cartilage.