Graphene hydrogel and method for using the same
AssigneesUniversity of South Florida, National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)
InventorsSubhra Mohapatra, Chunyan Wang
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Abstract
Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.
Claims19
A hydrogel composition comprising:
- at least two acrylated chitosan-graphene monomers, where each chitosan-graphene monomer comprises:
- carboxylic acid functionalized graphene, where the chitosan component of the chitosan graphene-monomer is covalently bonded to the carboxylic acid functionalized graphene component of the chitosan-graphene monomer;
- and polyethylene (glycol) diacrylate (PEGDA), where the PEGDA covalently crosslinks the at least two acrylated chitosan-graphene monomers.
A temperature responsive hydrogel composition comprising:
- at least two acrylated chitosan-graphene monomers, where each chitosan-graphene monomer comprises:
- carboxylic acid functionalized graphene, where the chitosan component of the chitosan graphene-monomer is covalently bonded to the carboxylic acid functionalized graphene component of the chitosan-graphene monomer;
- polyethylene (glycol) diacrylate (PEGDA), where the PEGDA covalently crosslinks the at least two acrylated chitosan-graphene monomers;
- and
- N-Isopropylacrylamide (NIPAM), where the NIPAM crosslinks at least one of the acrylated chitosan graphene monomers.
Dependencies are inferred from the claim text.