# US 9,433,677 B2 · Thermal treatment of a pilosebaceous unit with metal nanoparticles in surfactant containing solutions

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- Number: US 9,433,677 B2
- Document ID: US9433677B2
- Status: Granted
- Kind: B2
- Application number: 14/471,330
- Filed: 2014-08-28
- Published: 2015-01-01
- Granted: 2016-09-06
- Earliest claimed: 2010-08-27
- Assignees: Sienna Biopharmaceuticals, Inc.
- Applicants: Sienna Biopharmaceuticals, Inc.
- Inventors: Todd James Harris; Alice Ann Chen Kim
- Web page: https://patentgrep.com/patent/US9433677B2

## CPC

- A61B 18/06: caused by chemical reaction {, e.g. moxaburners}
- A61B 17/50: Instruments {, other than pincettes or toothpicks,} for removing foreign bodies from the human body (surgical pincettes, i.e. surgical tweezers, A61B17/30)
- A61B 18/18: by applying electromagnetic radiation, e.g. microwaves
- A61B 18/203: {applying laser energy to the outside of the body}
- A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)}
- A61K 8/0245: {Specific shapes or structures not provided for by any of the groups of A61K8/0241}
- A61K 8/0283: {Matrix particles}
- A61K 8/11: Encapsulated compositions
- A61K 8/19: containing inorganic ingredients
- A61K 8/29: Titanium; Compounds thereof
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/5115: {Inorganic compounds}
- A61K 9/5123: {Organic compounds, e.g. fats, sugars}
- A61K 9/5146: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides}
- A61K 9/5153: {Polyesters, e.g. poly(lactide-co-glycolide)}
- A61K 41/0052: {Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy}
- A61K 41/0057: {Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent}
- A61N 5/0616: {Skin treatment other than tanning}
- A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent}
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/06: Antipsoriatics
- A61P 17/08: Antiseborrheics
- A61P 17/10: Anti-acne agents
- A61P 17/12: Keratolytics, e.g. wart or anti-corn preparations
- A61P 17/14: for baldness or alopecia
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/02: for peripheral neuropathies
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 9/00: Preparations for removing hair or for aiding hair removal
- A61Q 9/04: Depilatories
- A61Q 19/00: Preparations for care of the skin
- A61B 2018/00452: {Skin}
- A61B 2018/00458: {Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains}
- A61B 2018/0047: {Upper parts of the skin, e.g. skin peeling or treatment of wrinkles}
- A61B 2018/00476: {Hair follicles}
- A61B 2018/00577: {Ablation}
- A61B 2018/00791: {Temperature}
- A61B 2018/00809: {measured thermochromatically}
- A61B 2018/068: {none of the reactants being oxygen}
- A61K 9/0009: {involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis}
- A61K 9/009: {Sachets, pouches characterised by the material or function of the envelope (with gastric retention A61K9/0065; sachets which are not administered but function merely as a container are classified according to the content, e.g. sachets comprising powder for reconstitution of a drink A61K9/0095)}
- A61K 2800/413: Nanosized, i.e. having sizes below 100 nm
- A61K 2800/621: by inorganic compounds
- A61K 2800/622: by organic compounds
- A61K 2800/624: by macromolecular compounds
- A61K 2800/81: Preparation or application process involves irradiation
- A61N 5/0617: {Hair treatment}
- A61N 5/0624: {for eliminating microbes, germs, bacteria on or in the body}
- A61N 5/0625: {Warming the body, e.g. hyperthermia treatment}
- A61N 5/067: using laser light
- A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092})
- A61N 2005/0659: {infrared}
- A61N 2007/0034: {Skin treatment}
- A61Q 19/06: for countering cellulitis
- A61Q 19/08: Anti-ageing preparations
- B82Y 5/00: Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES

## Abstract

Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of a pilosebaceous unit with metal nanoparticles in surfactant containing solutions are disclosed.

## Claims

### Claim 1

A method of localizing thermal damage to a pilosebaceous unit, comprising:
topically applying a composition comprising a surfactant and nanoparticles to a skin surface;
wherein the nanoparticles have at least one peak absorption wavelength selected from the group consisting of: 755 nm, 800-810 nm, and 1064 nm,
wherein the nanoparticles are unassembled,
wherein the nanoparticles are provided in a concentration of 109 to 1016 particles per ml of the composition
wherein the nanoparticles comprise a conductive metal portion comprising at least one of gold, silver, and platinum,
wherein the nanoparticles comprise a coating that coats the conductive metal portion;
targeting a pilosebaceous unit by redistributing a portion of the composition of nanoparticles from the skin surface to the pilosebaceous unit while a remaining portion of the composition is left on the skin surface;
removing the remaining portion of the composition from the skin surface; and
irradiating the composition of nanoparticles with an energy source to induce a surface plasmon in said nanoparticles, thereby localizing thermal damage to said pilosebaceous unit.

### Claim 2 (depends on 1)

The method of claim 1, wherein the surfactant comprises at least one nonionic surfactant.

### Claim 3 (depends on 1)

The method of claim 1, wherein the surfactant comprises sodium dodecyl sulfate.

### Claim 4 (depends on 1)

The method of claim 1, further comprising:
a cosmetically acceptable carrier,
wherein the surfactant is provided in an amount between 0.1 and about 10.0% weight-to-weight of the cosmetically acceptable carrier,
wherein the nanoparticles are plasmonic and have an optical density of 10 O.D. to 5,000 O.D. within an infrared light range,
wherein the composition comprises a gel or a cream.

### Claim 5 (depends on 1)

The method of claim 1, wherein redistributing the composition of nanoparticles comprises distribution with at least one of a massage device and an ultrasound device configured for bubble formation or liquid micro streaming.

### Claim 6 (depends on 1)

The method of claim 1,
wherein the conductive metal portion is a silver nanoplate,
wherein the coating is a non-metal silica coating,
wherein the coating is less conductive than the conductive metal portion, and
wherein the nanoplate has a dimension in a range of 10-100 nm.

### Claim 7

A method of localizing thermal damage to a pilosebaceous unit with a surfactant composition, comprising:
topically applying a composition comprising nanoparticles and a surfactant to a skin surface,
wherein the nanoparticles comprise a conductive metal portion comprising at least one of gold, silver, and platinum,
wherein the nanoparticles comprise a coating that coats the conductive metal portion;
wherein the nanoparticles are unassembled,
wherein the nanoparticles are provided in a range of 109 to 1016 particles in the composition;
distributing a portion of the composition from the skin surface to a portion of a pilosebaceous unit while a remaining portion of the composition is left on the skin surface;
removing the remaining portion of the composition from the skin surface; and
exposing the composition to an energy wavelength in a range selected from the group consisting of: 755 nm, 800-810 nm, and 1064 nm, thereby inducing a surface plasmon in said nanoparticles, thereby localizing thermal damage to said portion of the pilosebaceous unit.

### Claim 8 (depends on 7)

The method of claim 7, wherein the surfactant comprises at least one nonionic surfactant.

### Claim 9 (depends on 7)

The method of claim 7, wherein the conductive metal portion comprises gold and the coating comprises polyethylene glycol (PEG).

### Claim 10 (depends on 7)

The method of claim 7, further comprising:
a cosmetically acceptable carrier,
wherein the surfactant is sodium dodecyl sulfate,
wherein the conductive metal portion is a silver nanoplate having a dimension in a range of 1-1,000 nm, and
wherein the coating is less conductive than the conductive metal portion.

### Claim 11 (depends on 7)

The method of claim 7, further comprising:
pre-treating the skin surface, prior to exposing the composition to the energy wavelength, to increase distribution from the skin surface to the pilosebaceous unit, wherein pre-treating the skin surface comprises at least one of the group consisting of: hair removal, fractionated photothermolysis laser treatment, mechanical exfoliation, and chemical exfoliation.

### Claim 12 (depends on 7)

The method of claim 7, wherein distributing the composition of nanoparticles comprises distribution with at least one of the group consisting of an ultrasound device and a massage device.

### Claim 13 (depends on 7)

The method of claim 7, wherein the conductive metal portion is a nanoplate, wherein the coating comprises silica, and wherein the nanoplate has a dimension in a range of 100-250 nm.

### Claim 14 (depends on 7)

The method of claim 7, wherein the conductive metal portion is a silver nanoplate, wherein the coating comprises one or more of silica and polyethylene glycol (PEG) wherein the nanoplate has a dimension in a range of 1-1,000 nm.

### Claim 15 (depends on 7)

The method of claim 7, wherein the nanoparticles are plasmonic nanoparticles, wherein the nanoparticles have a dimension in a range of 1-1,000 nm, and wherein the portion of the pilosebaceous unit comprises one or more structures consisting of: a hair shaft, a hair follicle, a sebaceous gland, and a hair follicle infundibulum.

### Claim 16

A method of treating a pilosebaceous unit with a surfactant composition, comprising:
applying a composition comprising a surfactant and nanoparticles to a skin surface,
wherein the nanoparticles have a concentration of 109 to 1016 particles per ml of the composition, wherein the nanoparticles are unassembled,
wherein the nanoparticles comprise at least one of gold, silver, and platinum,
distributing a portion of the composition of from the skin surface to a portion of a pilosebaceous unit while a remaining portion of the composition is left on the skin surface;
wherein the nanoparticles comprise a coating,
removing the remaining portion of the composition from the skin surface, and
exposing the composition of nanoparticles to an energy wavelength, thereby localizing thermal damage to said portion of the pilosebaceous unit.

### Claim 17 (depends on 16)

The method of claim 16, further comprising:
pre-treating the skin surface to increase delivery of the nanoparticles to the portion of the pilosebaceous unit with at least one of the group consisting of shaving, waxing, peeling, a fractionated photothermolysis laser treatment, cyanoacrylate surface peeling, a calcium thioglycolate treatment, a surface exfoliation, a mechanical exfoliation, a salt glow, a microdermabrasion, a chemical exfoliation, a chemical exfoliation with an enzyme, a chemical exfoliation with alphahydroxy acid, and a chemical exfoliation with betahydroxy acid;
wherein distributing the composition of nanoparticles in contact with the skin surface comprises distribution with a mechanical vibration device; and
wherein exposing the composition of nanoparticles to the energy wavelength induces a surface plasmon in said nanoparticles.

### Claim 18 (depends on 16)

The method of claim 16,
wherein distributing the composition of nanoparticles in contact with the skin surface comprises distribution with at least one of the group consisting of an ultrasound device and a massage device;
wherein the energy wavelength is between 500 nm and 1200 nm,
wherein exposing the composition of nanoparticles to the energy wavelength induces a surface plasmon in said nanoparticles.

### Claim 19 (depends on 16)

The method of claim 16,
wherein the nanoparticles are nanoplates,
wherein the nanoparticles have an optical density of 10 O.D. to 5,000 O.D. within an infrared light range and the concentration is 1011 to 1013 particles per ml of the composition;
wherein the surfactant comprises sodium dodecyl sulfate, and
wherein exposing the composition of nanoparticles to the energy wavelength induces a surface plasmon in said nanoparticles.

### Claim 20 (depends on 16)

The method of claim 16, further comprising:
a cosmetically acceptable carrier,
wherein the energy wavelength is selected from the group consisting of: 755 nm, 800-810 nm, and 1064 nm,
wherein the surfactant is nonionic, and
wherein distributing the composition of nanoparticles comprises distribution with at least one of the group consisting of an ultrasound device, a high pressure air flow device, a high pressure liquid flow device, and a vacuum device.