# US 9,433,666 B2 · Indoleamine 2,3-dioxygenase based immunotherapy

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 9,433,666 B2
- Document ID: US9433666B2
- Status: Granted
- Kind: B2
- Application number: 12/988,124
- Filed: 2009-04-17
- Published: 2011-12-29
- Granted: 2016-09-06
- Earliest claimed: 2008-04-17
- Assignees: IO Bioech ApS
- Applicants: Mads Hald Andersen; Per Thor Straten
- Inventors: Mads Hald Andersen; Per Thor Straten
- Web page: https://patentgrep.com/patent/US9433666B2

## CPC

- A61K 38/2013: {IL-2}
- A61K 38/193: {Colony stimulating factors [CSF]}
- A61K 39/001154: {Enzymes}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 35/00: Antineoplastic agents
- A61P 37/04: Immunostimulants
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C12N 9/0069: {acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)}
- C12Y 113/11052: Indoleamine 2,3-dioxygenase (1.13.11.52), i.e. indoleamine 2,3-dioxygenase 1
- A61K 2039/5158: {Antigen-pulsed cells, e.g. T-cells}
- A61K 2039/55566: {Emulsions, e.g. Freund's adjuvant, MF59}
- A61K 2039/572: {cytotoxic response}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Y: ENZYMES

## Abstract

The present invention relates to the field of prophylaxis and therapy of cancer. In particular there is provided a protein Indoleamine 2,3-dioxygenase (IDO) or peptide fragments here of that are capable of eliciting anti-cancer immune responses. Specifically, the invention relates to the use of DO or peptides derived here from or IDO specific T-cells for treatment of cancer. The invention thus relates to an anti-cancer vaccine which optionally may be used in combination with other immunotherapies and to IDO specific T-cells adoptively transferred or induced in vivo by vaccination as a treatment of cancer. It is an aspect of the invention that the medicaments herein provided may be used in combination with cancer chemotherapy treatment. A further aspect relates to the prophylaxis and therapy of infections by the same means as described above. The use of IDO and immunogenic peptide fragments hereof in cancer and infection treatment, diagnosis and prognosis is also provided.

## Claims

### Claim 1

A vaccine composition, comprising:
a) an isolated immunogenically active peptide fragment of Indoleamine 2,3-dioxygenase (IDO) of SEQ ID NO: 1, wherein the amino acid sequence of the immunogenically active peptide fragment consists of SEQ ID NO: 6; and
an adjuvant
for use as a medicament.

### Claim 2 (depends on 1)

The vaccine composition according to claim 1, wherein said immunogenically active peptide fragment
consists of SEQ ID NO: 6.