# US 9,433,657 B2 · Healthcare food with anti-diabetic effect and preparation method thereof

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- Number: US 9,433,657 B2
- Document ID: US9433657B2
- Status: Granted
- Kind: B2
- Application number: 14/456,868
- Filed: 2014-08-11
- Published: 2016-02-11
- Granted: 2016-09-06
- Earliest claimed: 2013-08-12
- Assignees: Rose Cheung
- Applicants: Rose Cheung
- Inventors: Rose Cheung
- Web page: https://patentgrep.com/patent/US9433657B2

## CPC

- A61K 36/74: Rubiaceae (Madder family)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 9/1652: {Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623)}
- A61K 9/1682: {Processes}
- A61K 35/12: Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells (vaccines or medicinal preparations containing antigens or antibodies A61K39/00)
- A61K 36/752: Citrus, e.g. lime, orange or lemon
- A61K 36/8994: Coix (Job's tears)
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A healthcare foodstuff having an anti-diabetic effect and effective for treating type 2 diabetes mellitus. The healthcare foodstuff comprises effective ingredients and adjuvant(s), including Paederia scandens, coicis semen, pork and citri reticulatae pericarpium. Also disclosed is method of manufacturing the healthcare foodstuff useful in the treatment of type 2 diabetes mellitus.

## Claims

### Claim 1

A healthcare foodstuff having an anti-diabetic effect, wherein said healthcare foodstuff comprises effective ingredients and one or more adjuvants, in which the effective ingredients comprise Paederia scandens, coicis semen, pork and citri reticulatae pericarpium, and wherein the Paederia scandens, coicis semen, pork and citri reticulatae pericarpium are water extracts from respective medical material thereof, and the adjuvant is water-soluble starch.

### Claim 2 (depends on 1)

The healthcare foodstuff according to claim 1, wherein the weight ratio of Paederia scandens, coicis semen, pork and citri reticulatae pericarpium in the effective ingredients is approximately 12:6:6:1.

### Claim 3 (depends on 1)

The healthcare foodstuff according to claim 1, wherein the healthcare foodstuff is prepared by a method comprising the steps of:
extracting the effective ingredients and decocting in water twice to obtain to decoctions;
concentrating the two decoctions via filtration and vacuum concentration and evaporation; and
sieving a filtrate that results from the concentrating step until a plaster is obtained.

### Claim 4 (depends on 3)

The healthcare food with anti-diabetic effect of claim 3, wherein the decoction steps comprise:
during the first decoction, adding water in an amount of 7 times of the effective ingredients, soaking 30 min and decocting for 1 hour; and
during the second decoction, adding water in an amount of 6 times of the effective ingredients, and decocting for 1 hour.

### Claim 5 (depends on 4)

The healthcare foodstuff according to claim 4, wherein the healthcare foodstuff can be formulated into tablets, capsules, oils, granules, dripping pills or oral solutions.

### Claim 6 (depends on 5)

The healthcare foodstuff according to claim 5, wherein the healthcare foodstuff is used to treat type 2 diabetes mellitus.

### Claim 7 (depends on 5)

The healthcare foodstuff according to claim 5, wherein the granules are prepared by a method comprising the steps of:
spray dry granulation, wherein a plaster filtrate comprising the effective ingredients and a soluble starch are heated in a spray drying granulator to obtain dry powder, the dry powder undergoes spray dry granulation; and
dry granulation, wherein the dry powder is stabilized to form extruded strips, the strips are crushed, sieved, filtered and dry granulated to form granules.

### Claim 8 (depends on 7)

The healthcare foodstuff according to claim 7, wherein the parameters for the spray drying process in the spray drying step are: inlet air temperature is 115° C.-125° C.; outlet air temperature is 90° C.-110° C.; and minus pressure in spray dryer is −8 to −12 Pa.

### Claim 9 (depends on 8)

The healthcare foodstuff according to claim 8, wherein an atomized state must be monitored at all times during the spray drying process, and the spray drier is vibrated periodically until dry powders are obtained.

### Claim 10 (depends on 7)

The healthcare foodstuff according to claim 7, wherein the inlet air speed, outlet air speed and feeding rate in the spray granulation step should be well controlled to afford granules with uniform size.