# US 9,433,641 B2 · Skin external composition comprising a salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,641 B2 - Document ID: US9433641B2 - Status: Granted - Kind: B2 - Application number: 14/450,637 - Filed: 2014-08-04 - Published: 2014-12-25 - Granted: 2016-09-06 - Earliest claimed: 2009-10-19 - Assignees: Won Seog Choi - Applicants: Won Seog Choi; Dong-Yeul Kwon - Inventors: Won Seog Choi; Dong-Yeul Kwon - Web page: https://patentgrep.com/patent/US9433641B2 ## CPC - A61K 33/14: Alkali metal chlorides; Alkaline earth metal chlorides - A61K 8/19: containing inorganic ingredients - A61K 8/60: Sugars; Derivatives thereof - A61K 8/965: {of inanimate origin} - A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants} - A61K 9/2013: {Organic compounds, e.g. phospholipids, fats} - A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms - A61K 31/7016: Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032) - A61K 33/20: Elemental chlorine; Inorganic compounds releasing chlorine - A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin - A61Q 19/005: {Preparations for sensitive skin} - A61K 9/2009: {Inorganic compounds} - A61K 9/2018: {Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract A skin external composition comprising a combination of salt and sugar as an active ingredient in an amount effective to treat and prevent vaginosis, together with a pharmaceutically acceptable carrier, and the use thereof. ## Claims ### Claim 1 A method of treatment comprising administering to a mammal in need of treatment for a bacterial vaginosis infection a composition, wherein the composition is placed in a vagina of the mammal and the composition comprises: melted sodium chloride and glucose; wherein the melted sodium chloride and the glucose are 20 to 99.99% by weight of the composition and wherein the weight ratio of melted sodium chloride to the glucose is 1:1-1:30, and wherein the bacterial vaginosis infection is a Gardnerella vaginalis infection. ### Claim 2 (depends on 1) The method of claim 1, wherein the composition further comprises a liquid selected from the group consisting of distilled water, a buffered solution, an isotonic solution, a physiological saline, an oil, propylene glycol, ethanol and isopropyl myristate. ### Claim 3 (depends on 1) The method of claim 1, wherein the treatment is selected from the group consisting of alleviation of the Gardnerella vaginalis infection and elimination of the Gardnerella vaginalis infection. ### Claim 4 (depends on 1) The method of claim 1, wherein administering to the mammal comprises administering an amount of the composition ranging from 0.001 mg to 1000 mg per kilogram of body weight of the mammal. ### Claim 5 (depends on 4) The method of claim 4, wherein the amount of the composition ranges from 0.01 mg to 100 mg per kilogram of body weight of the mammal. ### Claim 6 (depends on 1) The method of claim 1, wherein the composition is administered from once a day to several times per day. ### Claim 7 (depends on 1) The method of claim 1, wherein the composition further comprises a compound selected from the group consisting of an antibiotic, a dye, and a flavor at a concentration from 0.1% to 20% by weight of the composition. ### Claim 8 (depends on 1) The method of claim 1, wherein the composition is selected from the group consisting of a topical preparation and an insert preparation. ### Claim 9 (depends on 8) The method of claim 8, wherein the topical preparation is selected from the group consisting of a cleansing liquid, a gel, a jelly, a foam, a cream, an ointment, a lotion, a balm, a patch, a paste, a spray solution, and an aerosol. ### Claim 10 (depends on 9) The method of claim 9, wherein the topical preparation is a cleansing liquid. ### Claim 11 (depends on 8) The method of claim 8, wherein the insert preparation is selected from the group consisting of a tablet, a capsule, a film, a sponge, a tampon and pad. ### Claim 12 (depends on 11) The method of claim 11, wherein the insert preparation is a tablet. ### Claim 13 A method of treatment comprising administering to a mammal in need of treatment for a bacterial vaginosis infection a composition, wherein the composition is placed in a vagina of the mammal and the composition comprises: melted Shinan sea salt and glucose; wherein the melted Shinan sea salt and the glucose are 20 to 99.99% by weight of the composition and wherein the weight ratio of melted Shinan sea salt to the glucose is 1:1-1:30, and wherein the bacterial vaginosis infection is a Gardnerella vaginalis infection. ### Claim 14 (depends on 13) The method of claim 13, wherein the composition further comprises a liquid selected from the group consisting of distilled water, a buffered solution, an isotonic solution, a physiological saline, an oil, propylene glycol, ethanol and isopropyl myristate. ### Claim 15 (depends on 13) The method of claim 13, wherein the treatment is selected from the group consisting of alleviation of the Gardnerella vaginalis infection and elimination of the Gardnerella vaginalis infection. ### Claim 16 (depends on 13) The method of claim 13, wherein administering to the mammal comprises administering an amount of the composition ranging from 0.001 mg to 1000 mg per kilogram of body weight of the mammal. ### Claim 17 (depends on 16) The method of claim 16, wherein the amount of the composition ranges from 0.01 mg to 100 mg per kilogram of body weight of the mammal. ### Claim 18 (depends on 13) The method of claim 13, wherein the composition is administered from once a day to several times per day. ### Claim 19 (depends on 13) The method of claim 13, wherein the composition further comprises a compound selected from the group consisting of an antibiotic, a dye, and a flavor at a concentration from 0.1% to 20% by weight of the composition. ### Claim 20 (depends on 13) The method of claim 13, wherein the composition is selected from the group consisting of a topical preparation and an insert preparation. ### Claim 21 (depends on 20) The method of claim 20, wherein the topical preparation is selected from the group consisting of a cleansing liquid, a gel, a jelly, a foam, a cream, an ointment, a lotion, a balm, a patch, a paste, a spray solution, and an aerosol. ### Claim 22 (depends on 21) The method of claim 21, wherein the topical preparation is a cleansing liquid. ### Claim 23 (depends on 20) The method of claim 20, wherein the insert preparation is selected from the group consisting of a tablet, a capsule, a film, a sponge, a tampon, and pad. ### Claim 24 (depends on 23) The method of claim 23, wherein the insert preparation is a tablet.