# US 9,433,629 B2 · Formulation for regeneration of bone, cartilage, teeth, and periodontium and treatment of tumors and cysts

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- Number: US 9,433,629 B2
- Document ID: US9433629B2
- Status: Granted
- Kind: B2
- Application number: 14/809,417
- Filed: 2015-07-27
- Published: 2015-11-26
- Granted: 2016-09-06
- Earliest claimed: 2014-05-23
- Applicants: Juan Paz Garcia; Brenda Astrid Paz Michel
- Inventors: Juan Paz Garcia; Brenda Astrid Paz Michel
- Web page: https://patentgrep.com/patent/US9433629B2

## CPC

- A61K 31/573: substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A61K 8/36: Carboxylic acids; Salts or anhydrides thereof
- A61K 8/362: Polycarboxylic acids
- A61K 8/63: Steroids; Derivatives thereof
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/676: {Ascorbic acid, i.e. vitamin C}
- A61K 38/28: Insulins
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61Q 7/00: Preparations for affecting hair growth
- A61K 2800/91: Injection
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention provides a formulation comprising a corticosteroid and an insulin analog or pharmaceutical compositions thereof. Also provided is a formulation comprising a corticosteroid, insulin lispro and at least one organic acid or pharmaceutical compositions thereof. The present invention provides methods for stimulating bone and/or cartilage growth, for treating tendon and/or ligament damage, for stimulating hair growth and/or reducing hair loss, for stimulating growth of a tooth and/or periodontium and for treating tumors and cysts of the jaw by administering the formulations described herein.

## Claims

### Claim 1

A formulation consisting of:
a corticosteroid and
ascorbic acid, malic acid and citric acid;
ascorbic acid, lactic acid and citric acid;
ascorbic acid, malic acid and lactic acid; or
ascorbic acid, malic acid, lactic acid and citric acid.

### Claim 2 (depends on 1)

The formulation of claim 1, wherein said corticosteroid is dexamethasone, cortisol, prednisone, prednisolone, methylprednisolone, betamethasone, triamcinolone, beclometasone, fludrocortisone acetate or deoxycorticosterone acetate.

### Claim 3 (depends on 2)

The formulation of claim 2, wherein said dexamethasone is contained in said formulation in an amount from about 0.5 mg/mL to about 10 mg/mL.

### Claim 4 (depends on 1)

A method for treating tumors and/or cysts of the jaw, comprising the step:
contacting said tumors and/or cysts of the jaw with the formulation of claim 1.

### Claim 5 (depends on 1)

A method for stimulating growth of a tooth and/or periodontium, comprising the step:
contacting said tooth and/or periodontium with the formulation of claim 1.