# US 9,433,627 B2 · Prostamides for the treatment of glaucoma and related diseases

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- Number: US 9,433,627 B2
- Document ID: US9433627B2
- Status: Granted
- Kind: B2
- Application number: 14/137,000
- Filed: 2013-12-20
- Published: 2014-04-17
- Granted: 2016-09-06
- Earliest claimed: 2004-10-06
- Assignees: Allergan, Inc.
- Applicants: Allergan, Inc.
- Inventors: David F. Woodward; Robert M. Burk
- Web page: https://patentgrep.com/patent/US9433627B2

## CPC

- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 31/137: Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
- A61K 31/4045: Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A61K 31/417: Imidazole-alkylamines, e.g. histamine, phentolamine
- A61K 31/4409: only substituted in position 4, e.g. isoniazid, iproniazid
- A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol
- A61K 31/557: Eicosanoids, e.g. leukotrienes {or prostaglandins}
- A61K 31/5575: having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A61K 31/559: having heterocyclic rings containing hetero atoms other than oxygen
- A61P 27/00: Drugs for disorders of the senses
- C07C 235/30: the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
- C07C 405/00: Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins {; Analogues or derivatives thereof}
- C07C 405/0041: {containing nitrogen}
- C07D 209/14: Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D 233/24: Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C07D 285/10: 1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
- C07D 409/12: linked by a chain containing hetero atoms as chain links
- C07C 2601/08: the ring being saturated
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.

## Claims

### Claim 1

A composition comprising an amide related to
a prostaglandin; and
a biogenic amine;
wherein the prostaglandin is prostaglandin F2α and the biogenic amine is dopamine.