# US 9,433,623 B2 · Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 9,433,623 B2
- Document ID: US9433623B2
- Status: Granted
- Kind: B2
- Application number: 14/427,915
- Filed: 2012-09-14
- Published: 2016-01-07
- Granted: 2016-09-06
- Earliest claimed: 2012-09-14
- Applicants: Elizabeth Levina
- Inventors: Elizabeth Levina
- Web page: https://patentgrep.com/patent/US9433623B2

## CPC

- A61K 31/515: Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
- A01N 43/54: 1,3-Diazines; Hydrogenated 1,3-diazines
- A61K 31/04: Nitro compounds
- A61K 31/11: Aldehydes
- A61K 31/15: Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) {; Imines (C—N=C)}
- A61P 31/04: Antibacterial agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to chemistry and pharmacology, in particular to synthetic biologically active substances of the pyrimidine series that have antimicrobial activity, and to the method of synthesis thereof. According to the invention there is provided a new substance with activity against gram positive bacteria, mycobacteria and fungi characterized in that it constitutes 5-(2-hydroxybenzylidene) derivatives of the pyrimidinone series with the general formula 1 where XI, X3 are selected from the group containing: H, halogen; N02; X2, X4 are selected from the group containing: H, halogen: Z is selected from the group containing: 0, NNH2, NOH, pei†iydropyrimidine-5-ytidene-2,4,6-trione, perhydropyrimidine-5-ylidene-2,4,6-trione, substituted at the nitrogen atom With alkyl, aryl or aralkyl group; Y is selected from the group containing: H, Na, Li, K.

## Claims

### Claim 1

Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi characterized in that it is a compound of the class of pyrimidine derivatives of salicylic aldehyde and perhydropyrimidine-2,4,6-triones with the general formula:
where X1, X3 are selected from the group containing: H, halogen; NO2;
X2, X4 are selected from the group containing: H, halogen;
Z is selected from the group containing: O, NNH2, NOH, perhydropyrimidine-5-ylidene-2,4,6-trione, perhydropyrimidine-5-ylidene-2,4,6-trione, substituted at the nitrogen atom with alkyl, aryl or aralkyl group;
Y is selected from the group containing: H, Na, Li, K.