# US 9,433,615 B2 · Animal parasite-control method using insect growth regulators > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,615 B2 - Document ID: US9433615B2 - Status: Granted - Kind: B2 - Application number: 12/206,648 - Filed: 2008-09-08 - Published: 2009-03-12 - Granted: 2016-09-06 - Earliest claimed: 2007-09-06 - Assignees: The Hartz Mountain Corporation - Applicants: William Ecker; Lance Hemsarth - Inventors: William Ecker; Lance Hemsarth - Web page: https://patentgrep.com/patent/US9433615B2 ## CPC - A61K 31/4402: only substituted in position 2, e.g. pheniramine, bisacodyl - A01N 43/40: six-membered rings - A01N 49/00: Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group [IMAGE cpc-sch-A01N-0948.gif], wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group [IMAGE cpc-sch-A01N-0949.gif], wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof (containing hydrocarbons A01N27/00) - A61K 31/09: having two or more such linkages - A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate - A61K 31/231: having one or two double bonds - A61K 31/415: 1,2-Diazoles - A61P 33/00: Antiparasitic agents - A61P 33/14: Ectoparasiticides, e.g. scabicides - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Methods and formulations for treating animal ectoparasites, effective against parasites such as fleas and ticks are provided. The methods comprise topically co-administering a non-mobile insect growth regulator, a mobile insect growth regulator, and an adulticide to the animal. Parasiticidal formulations for treating animal ectoparasites are also provided, which can be safe to use and avoids the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of two insect growth regulators and an additional insecticide. The topical formulation can be packaged together or packaged so that active components are stored separately prior to administering the topical insecticide formulation to the animal. ## Claims ### Claim 1 A method of treating parasitic infestation in a non-human animal, the method comprising: topically co-administering to the animal a formulation which includes a non-mobile insect growth regulator component comprising pyriproxyfen, a mobile insect growth regulator component comprising methoprene or hydroprene, and an adulticide component to the animal. ### Claim 2 (depends on 1) The method of claim 1 whereby the animal is a cat or a dog. ### Claim 3 (depends on 1) The method of claim 1 wherein the non-mobile insect growth regulator, the mobile insect growth regulator, and the adulticide are packaged in combination in a single container. ### Claim 4 (depends on 1) The method of claim 1 wherein the non-mobile insect growth regulator and the mobile insect growth regulator are packaged in a first container and the adulticide is packaged in a second container isolated from the contents of the first container, preventing interaction with the contents of the first container prior to administering the topical formulation. ### Claim 5 (depends on 1) The method of claim 1 wherein the mobile insect growth regulator comprises methoprene. ### Claim 6 (depends on 1) The method of claim 1 wherein the mobile insect growth regulator comprises hydroprene. ### Claim 7 An insecticidal formulation comprising an effective amount of a non-mobile insect growth regulator component comprising pyriproxyfen, a mobile insect growth regulator component comprising methoprene or hydroprene, and an adulticide component sufficient to reduce the parasitic infestation of a non-human animal treated with the formulation. ### Claim 8 (depends on 7) The formulation of claim 7, wherein the mobile insect growth regulator comprises methoprene. ### Claim 9 (depends on 7) The formulation of claim 7, wherein the mobile insect growth regulator comprises hydroprene. ### Claim 10 (depends on 7) The formulation of claim 7, wherein the amount of mobile insect growth regulator is between 0.01% and 10% of the formulation by weight. ### Claim 11 (depends on 7) The formulation of claim 7, wherein the amount of non-mobile insect growth regulator is between 0.005% and 5% of the formulation by weight. ### Claim 12 (depends on 7) The formulation of claim 7, wherein the adulticide comprises a synthetic pyrethroid. ### Claim 13 (depends on 7) The formulation of claim 7, wherein the adulticide comprises a natural pyrethrin. ### Claim 14 (depends on 7) The formulation of claim 7 wherein the adulticide comprises Etofenprox. ### Claim 15 (depends on 7) The formulation of claim 7, wherein the adulticide comprises a neonicotinoid. ### Claim 16 (depends on 7) The formulation of claim 7, wherein the adulticide comprises a phenylpyrazole. ### Claim 17 (depends on 7) The formulation of claim 7, wherein the amount of adulticide is between 1% and 90% of the formulation by weight. ### Claim 18 (depends on 7) The formulation of claim 7, wherein the non-mobile insect growth regulator, the mobile insect growth regulator, and the adulticide are dissolved in N,N dialkyl fatty acid amide. ### Claim 19 (depends on 18) The formulation of claim 18, wherein the amount of N,N dialkyl fatty acid amide is between 1% and 99% of the formulation by weight.