# US 9,433,608 B2 · Compositions and method for treatment of ischemic neuronal reperfusion injury

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- Number: US 9,433,608 B2
- Document ID: US9433608B2
- Status: Granted
- Kind: B2
- Application number: 14/273,370
- Filed: 2014-05-08
- Published: 2014-11-13
- Granted: 2016-09-06
- Earliest claimed: 2013-05-08
- Assignees: Howard University
- Applicants: Howard University
- Inventors: Harpal S. Mangat; Pradeep K. Karla
- Web page: https://patentgrep.com/patent/US9433608B2

## CPC

- A61K 31/4178: not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A61K 31/13: Amines {(A61K31/04 takes precedence)}
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/40: having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K 31/5513: 1,4-Benzodiazepines, e.g. diazepam {or clozapine}
- A61K 31/5517: condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A61K 31/59: Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K 31/765: Polymers containing oxygen
- A61K 38/05: Dipeptides
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- A62B 17/00: Protective clothing affording protection against heat or harmful chemical agents or for use at high altitudes (protective clothing or garments for work or sport A41D13/00; {e.g. overalls A41D13/02, surgical gowns A41D13/12; materials for protecting clothing A41D31/04}; protecting eyes or ears A61F9/00; composition of materials for protective clothing A62D5/00; life-saving garments for use at sea B63C; diving suits B63C11/02; flight suits B64D10/00; space suits B64G6/00; bullet-proof clothing F41H1/02)
- Y10T 428/2982: Particulate matter [e.g., sphere, flake, etc.]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A62B: DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING (valves specially adapted for medical use A61M39/00; life-saving devices, apparatus or methods specially adapted for use in water B63C9/00; divers' equipment B63C11/00; specially adopted for use with aircraft, e.g. parachutes, ejector seats, {B64D17/00, B64D25/10}; rescue devices peculiar to mining E21F11/00)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition may include at least a benzodiazepine class material. In another form, the composition may include at least two components selected from the group consisting of an antagonist of the type 3 ryanodine receptor, an NMDA blocker (antagonist), and a benzodiazepine class material which can be administered for ischemic neuronal reperfusion injury. In one form, all three components may be used.

## Claims

### Claim 1

A composition comprising:
an antagonist of a type 3 ryanodine receptor comprising at least one of val-dantrolene, val-val-dantrolene, and combinations thereof; and
at least one additional material selected from the group consisting of an NMDA blocker, a benzodiazepine class material, derivatives thereof, and combinations thereof.

### Claim 2 (depends on 1)

The composition of claim 1 wherein the benzodiazepine class material is selected from the group consisting of diazepam, midazolam, derivatives thereof and combinations thereof.

### Claim 3 (depends on 1)

The composition of claim 1 wherein the NMDA blocker is selected from the group consisting of memantine, derivatives thereof and combinations thereof.

### Claim 4 (depends on 1)

The composition of claim 1 further comprising at least one of Vitamin D, Vitamin E and a non-ionic surfactant.

### Claim 5

A kit for treatment of neuronal reperfusion injury with ischemic neuropathy comprising:
an antagonist of a type 3 ryanodine receptor comprising at least one of val-dantrolene, val-val-dantrolene, and combinations thereof; and
at least one additional material selected from the group consisting of an NMDA blocker, a benzodiazepine class material, derivatives thereof, and combinations thereof.

### Claim 6 (depends on 5)

The kit of claim 5 wherein both the NMDA blocker and the benzodiazepine class material are included.