# US 9,433,605 B2 · Method for promoting synthesis of tissue collagen

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- Number: US 9,433,605 B2
- Document ID: US9433605B2
- Status: Granted
- Kind: B2
- Application number: 13/856,566
- Filed: 2013-04-04
- Published: 2013-08-29
- Granted: 2016-09-06
- Earliest claimed: 2006-03-23
- Assignees: Kyowa Hakko Bio Co., Ltd.
- Applicants: Kyowa Hakko Bio Co., Ltd.
- Inventors: Toshikazu Kamiya; Ayako Kamimura; Yoko Kawada
- Web page: https://patentgrep.com/patent/US9433605B2

## CPC

- A61K 31/401: Proline; Derivatives thereof, e.g. captopril
- A23G 3/36: characterised by the composition {containing organic or inorganic compounds}
- A23G 3/44: containing peptides or proteins (containing dairy products A23G3/46)
- A23K 20/142: Amino acids; Derivatives thereof
- A23L 33/175: Amino acids
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 207/16: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.

## Claims

### Claim 1

A method for promoting synthesis of tissue collagen in skin, which comprises orally administering to a human having skin wrinkles or sagging an effective amount of a composition comprising hydroxyproline or a salt thereof, wherein
said hydroxyproline or salt thereof being the only active ingredients in said composition,
said skin wrinkles or sagging are induced by aging, and
the tissue collagen synthesized improves said skin wrinkles or sagging.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said composition comprises 0.5 to 70% by weight of hydroxyproline or a salt thereof as an active ingredient; and
a comestible carrier comprising at least one member selected from the group consisting of excipients, binders, disintegrating agents, lubricants, dispersants, suspending agents, emulsifiers, diluents, buffers, antioxidants and bacterial inhibitors, wherein
said oral preparation is in the form of a tablet, powder, granule, emulsion, syrup or capsule.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said composition is a solid.

### Claim 4 (depends on 1)

The method according to claim 1, wherein 5 to 5,000 mg of said hydroxyproline or salt thereof is administered to said human per day.

### Claim 5 (depends on 4)

The method according to claim 4, wherein said hydroxyproline or salt thereof is administered to said human at 0.1 to 100 mg per kg body weight per day.

### Claim 6 (depends on 5)

The method according to claim 5, wherein 50 to 5,000 mg of said hydroxyproline or salt thereof is administered to said human per day.

### Claim 7 (depends on 6)

The method according to claim 6, wherein said hydroxyproline or salt thereof is administered to said human at 1 to 100 mg per kg body weight per day.

### Claim 8 (depends on 7)

The method according to claim 7, wherein 500 to 5,000 mg of said hydroxyproline or salt thereof is administered to said human per day.

### Claim 9 (depends on 8)

The method according to claim 8, wherein said hydroxyproline or salt thereof is administered to said human at 10 to 100 mg per kg body weight per day.

### Claim 10 (depends on 1)

The method according to claim 1, wherein said composition comprises said hydroxyproline salt, said salt being selected from the group consisting of hydrochloride, sulfate, nitrate, phosphate, acetate, maleate, fumarate, citrate, malate, lactate, α-ketoglutarate, gluconate, caprylate, sodium, potassium, magnesium, calcium, aluminum, zinc, ammonium, tetramethylammonium, morpholine, piperidine, glycine, phenylalanine, lysine, asparate and glutamate salts.

### Claim 11 (depends on 1)

The method according to claim 1, wherein said composition further comprises at least one member selected from the group consisting of sucrose, sorbitol, fructose, polyethylene glycol, propylene glycol, sesame oil, olive oil, soybean oil, p-hydroxybenzoate, strawberry flavor and peppermint.

### Claim 12 (depends on 3)

The method according to claim 3, wherein said composition further comprises at least one member selected from the group consisting of lactose, white sugar, glucose, sucrose, mannitol, sorbitol, potato starch, wheat starch, corn starch, calcium carbonate, calcium sulfate, sodium hydrogencarbonate, sodium chloride, licorice powder, gentian powder, agar, gelatin powder, crystalline cellulose, carmellose sodium, carmellose calcium, sodium alginate, magnesium stearate, talc, hydrogenated vegetable oil, macrogol, silicone oil, polyvinyl alcohol, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, fatty acid esters and glycerin.