# US 9,433,601 B2 · Chewing gum compositions comprising cannabinoids

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- Number: US 9,433,601 B2
- Document ID: US9433601B2
- Status: Granted
- Kind: B2
- Application number: 14/684,109
- Filed: 2015-04-10
- Published: 2015-07-30
- Granted: 2016-09-06
- Earliest claimed: 2008-03-26
- Assignees: Stichting Sanammad
- Applicants: Stichting Sanammad
- Inventors: Philippus Anne Van Damme; George Evgeniyevich Anastassov
- Web page: https://patentgrep.com/patent/US9433601B2

## CPC

- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 9/0058: {Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00)}
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- B65D 75/36: one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages {, the recess or recesses being preformed (B65D73/0057, B65D73/0092 take precedence)}
- B65D 85/70: {for materials not otherwise provided for}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B65D: CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES

## Abstract

The present invention relates to a chewing gum composition comprising 0.01 to 15% by weight a cannabinoid or a derivative thereof, based on the total weight of the chewing gum composition, and to chewing gums and blistering packages comprising said chewing gums.

## Claims

### Claim 1

A chewing gum composition comprising, based on the total weight of the composition:
(a) 0.01 to 1% by weight of one or more cannabinoids, provided within internal voids of a solid cellulose carrier;
(b) 25 to 85% by weight of a gum base comprising at least one buffering agent;
(c) 10 to 35% by weight of at least one sweetening agent;
(d) 1 to 10% by weight of at least one flavouring agent; and
wherein 30% by weight of the cannabinoid is released within 5 minutes after ingestion, based on the total weight content of the cannabinoid in the chewing gum composition, and wherein the release starts within 3 minutes after ingestion.

### Claim 2 (depends on 1)

The chewing gum composition according to claim 1, wherein the cannabinoids comprise tetrahydrocannabinol (THC).

### Claim 3 (depends on 1)

The chewing gum composition according to claim 1, wherein the buffering agent is selected from the group consisting of acetates, glycinates, phosphates, carbonates, glycerophosphates, citrates, borates, and mixtures thereof.

### Claim 4 (depends on 1)

The chewing gum composition according to claim 1, wherein the sweetening agent is selected from the group consisting of xylitol, sorbitol, isomalt, aspartame, sucralose, acesulfame potassium, and saccharin.

### Claim 5 (depends on 1)

The chewing gum composition according to claim 1, wherein the flavouring agent is selected from the group consisting of menthol flavor, eucalyptus, mint flavor and/or L-menthol.

### Claim 6 (depends on 1)

The chewing gum composition according to claim 1, wherein the chewing gum composition comprises an antioxidant.

### Claim 7 (depends on 1)

The chewing gum composition according to claim 1, wherein the chewing gum composition comprises a pharmaceutically acceptable excipient selected from the group consisting of fillers, disintegrants, binders, lubricants, and antioxidants.

### Claim 8 (depends on 1)

The chewing gum composition according to claim 1, wherein the chewing gum composition is non-disintegrating.

### Claim 9 (depends on 1)

The chewing gum composition according to claim 1, wherein the chewing gum comprises natural cannabinoid obtained from cannabis.

### Claim 10 (depends on 1)

The chewing gum composition according to claim 1, wherein the sweetening agent is a sugar alcohol.

### Claim 11 (depends on 1)

The chewing gum composition according to claim 1, wherein the sweetening agent is selected from the group consisting of xylitol, sorbitol and/or isomalt.

### Claim 12 (depends on 1)

A blister package comprising a chewing gum composition according to claim 1.

### Claim 13 (depends on 1)

A method for treating or alleviating pain a mammal in need thereof, comprising administering to said mammal a chewing gum composition according to claim 1.

### Claim 14 (depends on 13)

The method according to claim 13, wherein the pain results from oral and cranio-maxillofacial surgery and/or disorders.

### Claim 15 (depends on 13)

The method according to claim 13, wherein the pain is chronic.

### Claim 16 (depends on 1)

The chewing gum composition according to claim 1, wherein the cannabinoids comprise THC and cannabidiol (CBD).