# US 9,433,595 B2 · Phytoestrogenic compositions for preventing or treating symptoms associated with menopause > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,595 B2 - Document ID: US9433595B2 - Status: Granted - Kind: B2 - Application number: 13/139,674 - Filed: 2008-12-26 - Published: 2011-10-13 - Granted: 2016-09-06 - Earliest claimed: 2008-12-26 - Assignees: Natural Endotech Co., Ltd. - Applicants: Jae-Soo Kim; Bo-Yeon Kwak; Kwontaek Yi; Jaekyoung Lee - Inventors: Jae-Soo Kim; Bo-Yeon Kwak; Kwontaek Yi; Jaekyoung Lee - Web page: https://patentgrep.com/patent/US9433595B2 ## CPC - A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327) - A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21) - A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)} - A61K 31/195: having an amino group - A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} - A61P 5/24: of the sex hormones - A61P 5/36: Antigestagens - A61P 15/12: for climacteric disorders - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention relates to a pharmaceutical composition for preventing or treating a menopausal symptom, comprising cinnamic acid, shanzhiside methylester or a mixture thereof as an active ingredient. The composition of the present invention exhibits an excellent estrogenic activity, and is effectively utilized for treating or preventing diverse menopausal symptoms generated by estrogen deficiency during perimenopause, menopause and postmenopause. ## Claims ### Claim 1 A method for alleviating one or more symptoms of menopause which comprises administering to a woman suffering from one or more menopausal symptoms induced by estrogen deficiency, and selected from the group consisting of sexual pain disorder, vaginal dryness, sleep disorder, mental awareness problem, arthralgia, osteoporosis, indigestion, urinary incontinence, fatigue, hot flashes caused from vasomotor instability, facial flushing, night sweat, palpitations, depression, anxiety, and irritability, a pharmaceutical composition having phytoestrogenic activity and consisting of: (a) a therapeutically effective amount of cinnamic acid, in combination with a therapeutically effective amount of shanzhiside methylester; and (b) a pharmaceutically acceptable carrier. ### Claim 2 A method for alleviating one or more symptoms of menopause, which comprises administering to a woman suffering from one or more menopausal symptoms induced by estrogen deficiency, and selected from the group consisting of sexual pain disorder, vaginal dryness, sleep disorder, mental awareness problem, arthralgia, osteoporosis, indigestion, urinary incontinence, fatigue, hot flashes caused from vasomotor instability, facial flushing, night sweat, palpitations, depression, anxiety, and irritability, a food composition having phytoestrogenic activity and consisting of: (a) a therapeutically effective amount of cinnamic acid in combination with a therapeutically effective amount of shanzhiside methylester; and (b) a food. ### Claim 3 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of sexual pain disorder and vaginal dryness. ### Claim 4 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of sleep disorder and mental awareness problem. ### Claim 5 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of arthralgia and osteoporosis. ### Claim 6 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of indigestion and urinary incontinence. ### Claim 7 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of fatigue and hot flashes caused from vasomotor instability. ### Claim 8 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of facial flushing and night sweat. ### Claim 9 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of palpitations and depression. ### Claim 10 (depends on 1) The method of claim 1, wherein said menopausal symptom is selected from the group consisting of anxiety and irritability. ### Claim 11 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of sexual pain disorder and vaginal dryness. ### Claim 12 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of sleep disorder and mental awareness problem. ### Claim 13 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of arthralgia and osteoporosis. ### Claim 14 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of indigestion and urinary incontinence. ### Claim 15 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of fatigue and hot flashes caused from vasomotor instability. ### Claim 16 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of facial flushing and night sweat. ### Claim 17 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of palpitations and depression. ### Claim 18 (depends on 2) The method of claim 2, wherein said menopausal symptom is selected from the group consisting of anxiety and irritability. ### Claim 19 (depends on 2) The method of claim 2, wherein said food comprises an ingredient selected from the group consisting of a protein, a carbohydrate, a fatty acid, a nutrient, a seasoning agent, a flavoring agent and a mixture thereof.