# US 9,433,594 B2 · Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof

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- Number: US 9,433,594 B2
- Document ID: US9433594B2
- Status: Granted
- Kind: B2
- Application number: 14/610,417
- Filed: 2015-01-30
- Published: 2016-08-04
- Granted: 2016-09-06
- Earliest claimed: 2008-01-09
- Assignees: Molecular Insight Pharmaceuticals, Inc.
- Applicants: Molecular Insight Pharmaceuticals, Inc.
- Inventors: John W. Babich; Craig Zimmerman; John Joyal; Kevin P. Maresca; John Marquis; Genliang Lu; Jian-cheng Wang; Shawn Hillier
- Web page: https://patentgrep.com/patent/US9433594B2

## CPC

- A61K 31/18: Sulfonamides (compounds containing a para-N-benzene-sulfonyl-N- group A61K31/63)
- A61K 31/4192: 1,2,3-Triazoles
- A61K 31/444: containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A61K 31/555: containing heavy metals, e.g. hemin, hematin, melarsoprol
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K 49/00: Preparations for testing in vivo
- A61K 51/04: Organic compounds
- A61K 51/0406: {Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines}
- A61K 51/041: {Heterocyclic compounds}
- A61K 51/0446: {having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil}
- A61K 51/0474: {complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group}
- A61K 51/0478: {complexes from non-cyclic ligands, e.g. EDTA, MAG3}
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- C07C 275/16: being further substituted by carboxyl groups
- C07C 311/16: having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07D 213/38: having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07F 13/005: {Compounds without a metal-carbon linkage}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

A method of imaging a region in a subject includes administering to the subject a complex of a metal chelated to a compound, and obtaining an image of the region in the subject.

## Claims

### Claim 1

A complex represented by any of the following formulae:
wherein n is 0 to 20, and M is a metal.

### Claim 2 (depends on 1)

The complex of claim 1, wherein the metal is a radionuclide.

### Claim 3 (depends on 1)

The complex of claim 1, where in the metal is yttrium, lutetium, gallium, or indium.

### Claim 4 (depends on 1)

A pharmaceutical formulation comprising the complex of claim 1 and a pharmaceutically acceptable excipient.

### Claim 5

A complex which is:
wherein n is 0 to 20, and M is yttrium, lutetium, gallium, or indium.