# US 9,433,579 B2 · Growth factor sensitive vesicle

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- Number: US 9,433,579 B2
- Document ID: US9433579B2
- Status: Granted
- Kind: B2
- Application number: 12/350,961
- Filed: 2009-01-09
- Published: 2009-11-05
- Granted: 2016-09-06
- Earliest claimed: 2008-05-02
- Applicants: Albert Wong
- Inventors: Albert Wong
- Web page: https://patentgrep.com/patent/US9433579B2

## CPC

- A61K 9/127: Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61P 35/00: Antineoplastic agents
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A generally spherical growth factor sensitive vesicle bearing growth factor receptors (12) having chemical compounds (14) covalently cross-linked to their non-growth factor binding domains. The chemical compounds are capable of associating to form larger chemical compounds (16) capable of destabilizing the vesicle. Methods for treating growth factor-overexpressing neoplasms are disclosed.

## Claims

### Claim 1

A growth factor sensitive vesicle, comprising:
an external shell which defines a generally spherical closed body;
said shell bearing at least two growth factor receptors having functional growth factor binding domains facing outside said shell, at least two of said growth factor receptors each having at least one non-growth factor binding domain covalently cross-linked to at least one chemical compound, at least two of said chemical compounds being capable of associating to form a chemical compound capable of destabilizing or permeabilizing said shell, permitting the release of the contents, if any, orginally enclosed within said shell.

### Claim 2 (depends on 1)

The growth factor sensitive vesicle of claim 1, wherein said growth factor sensitive vesicle is selected from a group consisting of a liposome, a niosome, a polyersome, and a vesosome.

### Claim 3 (depends on 1)

The growth factor sensitive vesicle of claim 1, wherein said chemical compound capable of destabilizing or permeabilizing said shell is a surface active agent.

### Claim 4 (depends on 2)

The growth factor sensitive vesicle of claim 2, wherein said chemical compound capable of destabilizing or permeabilizing said shell is a surface active agent.

### Claim 5 (depends on 4)

The growth factor sensitive vesicle of claim 4, wherein said contents originally enclosed within said shell are therapeutically effective for treating a growth factor-overexpressing neoplasm.