# US 9,433,564 B2 · Biphasic cosmetic > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,564 B2 - Document ID: US9433564B2 - Status: Granted - Kind: B2 - Application number: 14/707,369 - Filed: 2015-05-08 - Published: 2015-11-19 - Granted: 2016-09-06 - Earliest claimed: 2014-05-16 - Assignees: Restorsea, LLC - Applicants: Restorsea, LLC - Inventors: Ri An Choi; Enrique P. Alabata; Patricia S. Pao - Web page: https://patentgrep.com/patent/US9433564B2 ## CPC - A61K 8/03: Liquid compositions with two or more distinct layers - A01N 59/16: Heavy metals; Compounds thereof - A61K 8/19: containing inorganic ingredients - A61K 8/25: Silicon; Compounds thereof - A61K 8/27: Zinc; Compounds thereof - A61K 8/29: Titanium; Compounds thereof - A61K 8/31: Hydrocarbons - A61K 8/37: Esters of carboxylic acids - A61K 8/73: Polysaccharides - A61K 8/922: {of vegetable origin} - A61K 8/987: {of species other than mammals or birds} - A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics - A61Q 19/00: Preparations for care of the skin - A61K 2800/30: Characterized by the absence of a particular group of ingredients - A61K 2800/882: Mixing prior to application - A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations - A61Q 19/08: Anti-ageing preparations - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract A bi-phasic, non-emulsion cosmetic composition for application to skin includes a hydrophobic liquid phase and a hydrophilic liquid phase separate from but in contact with the hydrophobic liquid phase. Either or both phases may include active ingredients useful for cosmetic applications. When the composition is agitated, a temporary mixture of the two phases results, wherein the mixture contains globules of one of the phases suspended in the other. The mixture containing globules is applied to skin as a cosmetic. ## Claims ### Claim 1 A bi-phasic, non-emulsion cosmetic composition for application to skin comprising, together in one container: a hydrophobic liquid phase comprising squalane as a hydrophobic solvent; a hydrophilic liquid phase separate from the hydrophobic liquid phase and having a meniscus in contact with said hydrophobic phase; a first active agent in said hydrophobic liquid phase or said hydrophilic liquid phase; and sclerotium gum present in said hydrophilic liquid phase. ### Claim 2 (depends on 1) The cosmetic composition of claim 1, wherein said hydrophobic liquid phase is present in the composition from 25 to 60 volume percent. ### Claim 3 (depends on 1) The cosmetic composition of claim 1, wherein the first active agent is an algae extract. ### Claim 4 (depends on 1) The cosmetic composition of claim 1, wherein said first active agent is a protein soluble in said hydrophilic liquid phase. ### Claim 5 (depends on 4) The cosmetic composition of claim 4, wherein said protein is an enzyme having activity on human skin. ### Claim 6 (depends on 1) The cosmetic composition of claim 1, wherein said first active agent is a fish spawn protein isolate from hatching fish eggs. ### Claim 7 (depends on 1) The cosmetic composition of claim 1, further comprising an insoluble particulate present in said hydrophilic liquid phase. ### Claim 8 (depends on 1) The cosmetic composition of claim 1, wherein the composition does not contain a foaming agent. ### Claim 9 (depends on 1) The cosmetic composition of claim 1, further comprising a particulate selected from the group consisting of mica, gold flakes, metalized plastic flakes, fluorphlogopite, titanium dioxide, tin oxide, red iron oxide, and combinations of any two or more from the group. ### Claim 10 (depends on 1) The cosmetic composition of claim 1, further comprising a second active agent soluble in one of the phases, wherein one of the first and second active agents is soluble in the hydrophobic liquid phase, and the other of the first and second active agents is soluble in the hydrophilic liquid phase. ### Claim 11 (depends on 1) The cosmetic composition of claim 1, wherein said hydrophilic phase has a pH of between 5.6 and 7.9. ### Claim 12 (depends on 1) The cosmetic composition of claim 1, wherein the sclerotium gum is present in the hydrophilic liquid phase in a proportion of 0.23 grams sclerotium gum per 100 grams hydrophilic liquid phase. ### Claim 13 (depends on 1) The cosmetic composition of claim 1, further comprising a Lactobacillus fermentation filtrate. ### Claim 14 A bi-phasic, non-emulsion cosmetic composition for application to skin, the composition comprising: a hydrophobic liquid phase comprising squalane as a hydrophobic solvent; in contact with the hydrophobic liquid phase, a hydrophilic liquid phase comprising water as a hydrophilic solvent; and sclerotium gum and protein dissolved in the hydrophilic liquid phase. ### Claim 15 (depends on 14) The cosmetic composition of claim 14, further comprising at least one biocide. ### Claim 16 (depends on 14) The cosmetic composition of claim 14, wherein said protein is comprised in a fish spawn protein isolate from hatching fish eggs. ### Claim 17 (depends on 16) The cosmetic composition of claim 16, wherein said fish spawn protein isolate comprises choriolysin, a serine protease, a lectin, or a combination thereof. ### Claim 18 (depends on 16) The cosmetic composition of claim 16, wherein said fish spawn protein isolate is derived from salmon roe. ### Claim 19 (depends on 14) The cosmetic composition of claim 14, wherein the hydrophobic liquid phase comprises an algae extract, capric triglyceride, caprylic triglyceride, or a combination thereof. ### Claim 20 (depends on 14) The cosmetic composition of claim 14, comprising a solid particulate suspended in the hydrophilic liquid phase. ### Claim 21 (depends on 14) The cosmetic composition of claim 14, wherein the hydrophilic liquid phase comprises a solid particulate selected from the group consisting of mica, gold flakes, metalized plastic flakes, fluorphlogopite, titanium dioxide, tin oxide, iron oxide, and combinations of any two or more thereof. ### Claim 22 (depends on 14) The cosmetic composition of claim 14, further comprising a Lactobacillus fermentation filtrate. ### Claim 23 A biphasic, non-emulsion cosmetic composition comprising a hydrophobic phase in contact with an aqueous hydrophilic phase, wherein the hydrophobic phase comprises squalane, an algae extract, and caprylic/capric triglyceride; and the aqueous hydrophilic phase comprises sclerotium gum, Lactobacillus fermentation filtrate, polyepsilon-lysine, ascorbyl glucoside, Crocus sativus flower extract, salmon hatching fluid filtrate, and a particulate comprising gold flecks and inorganic glitter formed of titanium dioxide, tin oxide, iron oxide, and either fluorphlogopite or mica. ### Claim 24 (depends on 1) A process for applying an active ingredient to skin, comprising: providing the bi-phasic, non-emulsion cosmetic composition of claim 1; agitating the composition to form a mixture comprising globules of the hydrophobic phase suspended in the hydrophilic phase; and applying the mixture to skin. ### Claim 25 (depends on 14) A process for applying a protein to skin, comprising: providing the bi-phasic, non-emulsion cosmetic composition of claim 14; agitating the composition to form a mixture comprising globules of the hydrophobic phase suspended in the hydrophilic phase; and applying the mixture to skin. ### Claim 26 (depends on 1) A process for preparing the bi-phasic, non-emulsion cosmetic composition of claim 1, the process comprising: providing a hydrophobic liquid phase comprising squalane as a hydrophobic solvent, and a separate hydrophilic liquid phase comprising sclerotium gum, wherein at least one of the two phases contains an active agent; and introducing both phases into a container to form the bi-phasic, non-emulsion cosmetic composition of claim 1, with one phase layered on the other. ### Claim 27 (depends on 26) The process of claim 26, wherein the active agent is a fish spawn protein from hatching fish eggs. ### Claim 28 (depends on 26) The process of claim 26, wherein the cosmetic comprises a particulate ingredient that imparts sparkle to the composition.