# US 9,433,518 B2 · Medical device

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- Number: US 9,433,518 B2
- Document ID: US9433518B2
- Status: Granted
- Kind: B2
- Application number: 14/586,686
- Filed: 2014-12-30
- Published: 2015-07-16
- Granted: 2016-09-06
- Earliest claimed: 2004-03-31
- Assignees: Merlin Md Pte Ltd.
- Applicants: Merlin Md Pte Ltd.
- Inventors: Leon Rudakov; Michael O'Connor; Deepak Gandhi
- Web page: https://patentgrep.com/patent/US9433518B2

## CPC

- A61F 2/07: Stent-grafts
- A61B 17/12118: {for positioning in conjunction with a stent}
- A61F 2/90: characterised by a net-like or mesh-like structure
- A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F 2/915: with bands having a meander structure, adjacent bands being connected to each other
- A61F 2002/065: {Y-shaped blood vessels}
- A61F 2002/075: {the stent being loosely attached to the graft material, e.g. by stitching}
- A61F 2002/077: {having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve}
- A61F 2002/823: {Stents, different from stent-grafts, adapted to cover an aneurysm}
- A61F 2002/91541: {Adjacent bands are arranged out of phase}
- A61F 2002/91566: {connected trough to trough}
- A61F 2002/91575: {connected peak to trough}
- A61F 2002/91583: {by a bridge, whereby at least one of its ends is connected along the length of a strut between two consecutive apices within a band}
- A61F 2210/0076: multilayered, e.g. laminated structures
- A61F 2220/0008: Fixation appliances for connecting prostheses to the body
- A61F 2220/0016: with sharp anchoring protrusions, e.g. barbs, pins, spikes
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method for treating an aneurysm can include inserting a medical device partially in a first artery and partially in a third artery. The device can be expanded radially outwardly from a first position to a second position to engage an inner surface of the first artery and an inner surface of the third artery, so as to maintain a fluid pathway through said arteries. Further, the device can be positioned such that, when the device is in the second position, a porous membrane of the device is located at a neck of the aneurysm.

## Claims

### Claim 1

A method for treating a bifurcation or trifurcation aneurysm occurring on a first artery, the first artery and a second artery joining to a third artery, the method comprising:
inserting a medical device into the first and third arteries;
radially expanding the medical device into apposition with inner surfaces of the first and third arteries; and
positioning the medical device such that when expanded, a membrane of the medical device is located against a neck of the aneurysm to obstruct blood flow into the aneurysm, the membrane being secured to the medical device to maintain the position of the membrane relative to the medical device;
wherein the membrane is permeable and porous, the size of the pores of the membrane and the ratio of the material surface area of the membrane being such that blood supply to perforators and/or microscopic branches of main brain arteries is permitted to improve healing of the first artery but blood supply to the aneurysm is reduced.

### Claim 2 (depends on 1)

The method of claim 1, wherein a wall thickness of struts of the medical device is less than or equal to 0.0028″.

### Claim 3 (depends on 1)

The method of claim 1, wherein the membrane has fabricated pores between 20 and 100 microns in size.

### Claim 4 (depends on 1)

The method of claim 1, wherein the distance between adjacent pores does not exceed 75 microns.

### Claim 5 (depends on 1)

The method of claim 1, wherein the membrane comprises a plurality of polymeric strips.

### Claim 6 (depends on 1)

The method of claim 1, wherein the medical device comprises (a) an expandable frame having a plurality of struts and (b) a porous membrane that extends around and between the plurality of struts, wherein the membrane comprises a single sheet web portion that extends only in a central region, from a first strut of the plurality of struts to a second strut adjacent to the first strut, the first strut being spaced from the second strut at an interstitial spacing that is greater than a width of the first strut or a width of the second strut, the central region being (i) bounded radially between radially outermost edges and radially innermost edges of the first and second struts and (ii) bounded axially between the first and second struts, the web portion defining a web thickness that is less than a wall thickness of the first strut or a wall thickness of the second strut.

### Claim 7 (depends on 6)

The method of claim 6, wherein the membrane completely surrounds one or more of the plurality of struts.

### Claim 8 (depends on 1)

The method of claim 1, wherein membrane has a substantially uniform porosity.

### Claim 9

A method for treating a bifurcation or trifurcation aneurysm, in a patient, occurring at a first artery, the first artery and a second artery joining to a third artery, the method comprising:
inserting a medical device into the first artery and the third artery, the medical device comprising an expandable latticework frame having first and second struts that each define a radially outermost edge, a radially innermost edge, a circumferential strut width, and a wall thickness between the radially outermost and innermost edges, the medical device further comprising a porous membrane that extends around and between the first and second struts, the membrane having a single sheet web portion that, between the first and second struts, extends only within a central region being (i) bounded radially between the radially outermost edges and the radially innermost edges of the first and second struts and (ii) bounded circumferentially between the first and second struts, the web portion defining a web thickness that is less than the wall thickness of the first or second struts;
radially expanding the device into apposition with inner surfaces of the first and third arteries so as to maintain a fluid pathway through said arteries; and
positioning the device such that, when expanded, the porous membrane is located at a neck of the aneurysm;
wherein the membrane is configured to (i) reduce blood supply into the aneurysm, and (ii) permit blood supply through pores of the membrane and into perforators and/or microscopic branches of the first artery so as not to inhibit blood supply functions of the perforators and/or microscopic branches.

### Claim 10 (depends on 9)

The method of claim 9, wherein a distance between adjacent pores of the membrane does not exceed 75 microns.

### Claim 11 (depends on 9)

The method of claim 9, wherein the first strut is spaced from the second strut at an interstitial spacing that is greater than the strut width of the first or second struts.

### Claim 12 (depends on 9)

The method of claim 9, wherein the membrane has a substantially uniform porosity over a length extending from a distal end of the membrane to a proximal end of the membrane.

### Claim 13 (depends on 9)

The method of claim 9, wherein the membrane completely surrounds each of the first and second struts.

### Claim 14 (depends on 9)

The method of claim 9, wherein the wall thickness is less than or equal to 0.0028″.

### Claim 15

A method for treating an aneurysm, in a patient, the method comprising:
inserting a medical device in a first vessel, the medical device comprising (i) an expandable latticework frame having first and second struts that each define an axial strut width, a radially outermost edge, a radially innermost edge, and a wall thickness defined between the radially outermost edge and the radially innermost edge, and (ii) a comprises a single sheet porous membrane attached to the frame and extending circumferentially, between the first and second struts, only in a central region being (i) bounded circumferentially between the radially outermost edges and the radially innermost edges of the first and second struts and (ii) bounded axially between the first and second struts, a thickness of the membrane in the central region being less than the wall thickness of the first or second struts;
positioning the device such that the device and membrane is located at a neck of the aneurysm; and
expanding the device radially outwardly into apposition with an inner surface of the first vessel.

### Claim 16 (depends on 15)

The method of claim 15, wherein when the device is expanded, the membrane comprises pores with a size between about 20 microns and about 100 microns and a distance between adjacent pores is not larger than 100 microns, such that the membrane reduces blood flow into the aneurysm and permits blood supply to small branch vessels, branching from the first vessel, through the pores of the membrane so as not to inhibit blood supply functions of the small branch vessels.

### Claim 17 (depends on 15)

The method of claim 15, wherein the expanding comprises expanding the device radially outwardly from a first position to a second position such that, when the device is in the second position, a distal region of an exterior surface of the device engages an inner surface of the first vessel distal to the aneurysm, a proximal region of the exterior surface of the device engages an inner surface of the first vessel proximal to the aneurysm.

### Claim 18 (depends on 15)

The method of claim 15, wherein the first strut is spaced from the second strut at an interstitial spacing that is greater than the axial strut width of the first or second struts.

### Claim 19 (depends on 15)

The method of claim 15, wherein the porous membrane has a substantially uniform porosity.

### Claim 20 (depends on 15)

The method of claim 15, wherein the wall thickness is less than or equal to 0.0028″.

### Claim 21 (depends on 15)

The method of claim 15, wherein the membrane completely surrounds the first and second struts.