# US 9,433,459 B2 · Deposit ablation within and external to circulatory systems

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- Number: US 9,433,459 B2
- Document ID: US9433459B2
- Status: Granted
- Kind: B2
- Application number: 14/039,626
- Filed: 2013-09-27
- Published: 2014-01-30
- Granted: 2016-09-06
- Earliest claimed: 2010-07-13
- Assignees: ZOLL Medical Corporation
- Applicants: Zoll Medical Corporation
- Inventors: Mark Totman; Sheldon S. White; Michael R. Dupelle; Christopher Desmarais; Paul F. Prew
- Web page: https://patentgrep.com/patent/US9433459B2

## CPC

- A61B 18/14: Probes or electrodes therefor
- A61N 1/32: alternating or intermittent currents {(applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02)}
- A61B 2018/0041: {Removal of thrombosis}
- A61B 2018/00577: {Ablation}
- A61N 1/0408: {Use-related aspects}
- A61N 1/20: continuous direct currents
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Systems and methods of electrical stimulation for intra and extra vascular treatment of a subject are provided. The device includes a first electrode, a second electrode, and a controller. The controller is configured to apply an electrical current between the first and second electrodes. The electrical current follows a path between the first and second electrodes and through a portion of the subject that includes a blockage.

## Claims

### Claim 1

A method of ablating a blockage in a blood vessel of a subject, comprising:
positioning a first electrode internal to the subject and proximate to a first portion of an outer surface of a blood vessel that includes the blockage;
positioning a second electrode internal to the subject and proximate to a second portion of the outer surface of the blood vessel,
wherein the first electrode and the second electrode are positioned external to the blood vessel and proximate to the blockage; and
conducting pulses of an electrical current between the first electrode and the second electrode and along a path that includes the blockage, wherein the pulses are conducted at a frequency configured to ablate the blockage and facilitate blood flow in the blood vessel.

### Claim 2 (depends on 1)

The method of claim 1, wherein conducting pulses of the electrical current includes conducting pulses of an electrical current having an amplitude between approximately 2 milliamperes and 8 milliamperes at a frequency between approximately 50 and 100 pulses per minute for a duration of approximately 1-8 hours.

### Claim 3 (depends on 1)

The method of claim 1, wherein conducting pulses of the electrical current includes conducting pulses of an electrical current having an amplitude of approximately 15 milliamperes at a frequency between approximately 100 and 175 pulses per minute for a duration of approximately 30 to 75 minutes.

### Claim 4 (depends on 1)

The method of claim 1, wherein at least some of the pulses have pulse widths of approximately 175 milliseconds.