# US 9,433,392 B2 · Medical image processing apparatus, X-ray diagnostic apparatus, and medical image processing method > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,392 B2 - Document ID: US9433392B2 - Status: Granted - Kind: B2 - Application number: 14/551,253 - Filed: 2014-11-24 - Published: 2015-06-04 - Granted: 2016-09-06 - Earliest claimed: 2013-11-29 - Assignees: Toshiba Medical Systems Corporation - Applicants: Kabushiki Kaisha Toshiba; Toshiba Medical Systems Corporation - Inventors: Satoru Ohishi - Web page: https://patentgrep.com/patent/US9433392B2 ## CPC - A61B 6/469: {for selecting a region of interest [ROI]} - A61B 6/463: {characterised by displaying multiple images or images and diagnostic data on one display} - A61B 6/481: {involving the use of contrast agents} - A61B 6/504: {for diagnosis of blood vessels, e.g. by angiography} - A61B 6/5211: {involving processing of medical diagnostic data} - G06T 5/50: using two or more images, e.g. averaging or subtraction - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - G06T 2207/10116: X-ray image - G06T 2207/20224: Image subtraction - G06T 2207/30101: Blood vessel; Artery; Vein; Vascular - G06T 2210/41: Medical - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract According to one embodiment, a medical image processing apparatus includes an image data acquisition part, a range setting part and a blood vessel image generation part. The image data acquisition part receives one of X-ray contrast image and subtraction image, of an imaging region including blood vessels of an object. The subtraction image are generated by subtraction processing between the X-ray contrast image and non-contrast X-ray image. The range setting part sets a target range in the X-ray contrast image or subtraction image. The blood vessel image generation part derives time changes in concentrations of a contrast agent based on the X-ray contrast image or subtraction image, and generates blood vessel image having pixel values corresponding to times, at which concentrations of the contrast agent become a specific condition, within the target range and pixel values corresponding to concentrations of the contrast agent outside the target range. ## Claims ### Claim 1 A medical image processing apparatus comprising: an image data reception part configured to receive at least one of X-ray contrast image data and subtraction image data, of an imaging region including blood vessels of an object, the subtraction image data being generated by subtraction processing between the X-ray contrast image data and non-contrast X-ray image data; a range setting part configured to set a target range in the received X-ray contrast image data or the received subtraction image data; and a blood vessel image generation part configured to derive time changes in concentrations of a contrast agent based on the received X-ray contrast image data or the received subtraction image data, and generate blood vessel image data having pixel values corresponding to times, at which concentrations of the contrast agent become a specific condition, within the target range and pixel values corresponding to concentrations of the contrast agent outside the target range. ### Claim 2 (depends on 1) A medical image processing apparatus of claim 1, wherein said blood vessel image generation part is configured to generate the blood vessel image data according to time changes in concentrations, of the contrast agent, in a period when the contrast agent is flowing inside the target range, the period lying between an injection period when the contrast agent is being injected into the object, the blood vessel image data being generated based on the X-ray contrast image data or the subtraction image data corresponding to the injection period. ### Claim 3 (depends on 1) A medical image processing apparatus of claim 1, wherein said blood vessel image generation part is configured to make a color scale in which colors have been related to a range of the times at which the concentrations of the contrast agent in the target range become the specific condition, and generate blood vessel image data, having color pixel values, according to the color scale. ### Claim 4 (depends on 3) A medical image processing apparatus of claim 3, wherein said blood vessel image generation part is configured to make the color scale corresponding to the target range by contracting an initial color scale in a time direction, the initial color scale having initial colors related to a range of times at which concentrations of the contrast agent in the imaging region become the specific condition. ### Claim 5 (depends on 3) A medical image processing apparatus of claim 3, wherein said blood vessel image generation part is configured to make a color scale in which a color variation is periodically repeated multiple times, and generate the blood vessel image data according to the color scale, the color scale being related with the range of the times at which the concentrations of the contrast agent in the target range become the specific condition. ### Claim 6 (depends on 3) A medical image processing apparatus of claim 3, wherein said blood vessel image generation part is configured to make color scales between which the colors, related to the range of the times at which the concentrations of the contrast agent in the target range become the specific condition, vary temporally, and generate the blood vessel image data as a moving image whose colors vary temporally according to the color scales. ### Claim 7 (depends on 1) A medical image processing apparatus of claim 1, further comprising: a display part configured to superimpose and display X-ray contrast image data or subtraction image data in the target range of the blood vessel image data, the X-ray contrast image data or the subtraction image data in the target range corresponding to the blood vessel image data in the target range. ### Claim 8 (depends on 1) A medical image processing apparatus of claim 1, wherein said range setting part is configured to set a region as the target range, the region being designated by an operation of an input device. ### Claim 9 (depends on 1) A medical image processing apparatus of claim 1, wherein said range setting part is configured to set an area as the target range, the area lying in the imaging region, times at which concentrations of the contrast agent become the specific condition being within a specific time range in the area. ### Claim 10 (depends on 9) A medical image processing apparatus of claim 9, wherein said range setting part is configured to set the specific time range as a period between times at which concentrations of the contrast agent at different two points on a blood vessel become the specific condition, as, the two points being designated by an operation of an input device through a reference image in the imaging region. ### Claim 11 (depends on 9) A medical image processing apparatus of claim 9, wherein said range setting part is configured to set the specific time range as a time range designated by an operation of an input device. ### Claim 12 (depends on 1) A medical image processing apparatus of claim 1, wherein said range setting part is configured to detect a continuous target blood vessel region by tracking a blood vessel at a position in the target range, and remove a blood vessel region, unconnected with the target blood vessel region, from the target range, the position being designated by an operation of an input device. ### Claim 13 (depends on 12) A medical image processing apparatus of claim 12, wherein said range setting part is configured to track the blood vessel by first threshold processing of maximum concentrations of the contrast agent in the target range and second threshold processing of differences in times, at which concentrations of the contrast agent become the specific condition, between adjacent pixel positions in the target range. ### Claim 14 (depends on 1) A medical image processing apparatus of claim 1, wherein said blood vessel image generation part is configured to generate first blood vessel image data and second blood vessel image data individually in order to be able to display the first blood vessel image data and the second blood vessel image data in parallel, the first blood vessel image data having the pixel values corresponding to the times at which the concentrations of the contrast agent in the target range become the specific condition, the second blood vessel image data having pixel values corresponding to concentrations of the contrast agent in the imaging region. ### Claim 15 An X-ray diagnostic apparatus comprising: an imaging system configured to acquire at least X-ray contrast image data of an imaging region including blood vessels of an object; a range setting part configured to set a target range in the X-ray contrast image data or subtraction image data generated by subtraction processing between the X-ray contrast image data and non-contrast X-ray image data; and a blood vessel image generation part configured to derive time changes in concentrations of a contrast agent based on the X-ray contrast image data or the subtraction image data, and generate blood vessel image data having pixel values corresponding to times, at which concentrations of the contrast agent become a specific condition, within the target range and pixel values corresponding to concentrations of the contrast agent outside the target range. ### Claim 16 A medical image processing method comprising: receiving at least one of X-ray contrast image data and subtraction image data, of an imaging region including blood vessels of an object, the subtraction image data being generated by subtraction processing between the X-ray contrast image data and non-contrast X-ray image data; setting a target range in the received X-ray contrast image data or the received subtraction image data; and deriving time changes in concentrations of a contrast agent based on the received X-ray contrast image data or the received subtraction image data, and generating blood vessel image data having pixel values corresponding to times, at which concentrations of the contrast agent become a specific condition, within the target range and pixel values corresponding to concentrations of the contrast agent outside the target range.