# US 9,433,363 B1 · Method and system for high throughput evaluation of functional cardiac electrophysiology

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- Number: US 9,433,363 B1
- Document ID: US9433363B1
- Status: Granted
- Kind: B1
- Application number: 14/941,455
- Filed: 2015-11-13
- Granted: 2016-09-06
- Earliest claimed: 2015-06-18
- Assignees: Genetesis, Inc.
- Applicants: Genetesis, LLC
- Inventors: Vineet Erasala; Peeyush Shrivastava
- Web page: https://patentgrep.com/patent/US9433363B1

## CPC

- A61B 5/243: specially adapted for magnetocardiographic [MCG] signals
- A61B 5/0035: {adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography}
- A61B 5/0044: {for the heart}
- A61B 5/01: Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20)
- A61B 5/021: Measuring pressure in heart or blood vessels
- A61B 5/024: Measuring pulse rate or heart rate
- A61B 5/245: specially adapted for magnetoencephalographic [MEG] signals
- A61B 5/341: Vectorcardiography [VCG]
- A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)}
- A61B 5/7235: {Details of waveform analysis (detecting specific parameters of the electrocardiograph cycle A61B5/349)}
- A61B 5/7278: {Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals}
- A61B 5/7282: {Event detection, e.g. detecting unique waveforms indicative of a medical condition (cough events A61B5/0823; seizures A61B5/4094; sleep apnoea A61B5/4818)}
- A61B 5/743: {Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots}
- A61B 5/7475: {User input or interface means, e.g. keyboard, pointing device, joystick}
- A61B 6/032: {Transmission computed tomography [CT]}
- A61B 6/485: {involving fluorescence X-ray imaging}
- A61B 8/08: Clinical applications (A61B8/02, A61B8/04, A61B8/06 take precedence)
- A61B 5/02055: {Simultaneously evaluating both cardiovascular condition and temperature}
- A61B 2090/374: {NMR or MRI}
- A61B 2090/3762: {using computed tomography systems [CT]}
- A61B 2090/378: {using ultrasound}
- A61B 2562/0223: Magnetic field sensors
- A61B 2576/023: for the heart
- A61B 2576/026: for the brain
- G16H 30/40: for processing medical images, e.g. editing
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.

## Claims

### Claim 1

A system for evaluating an organ of an individual in need thereof, comprising:
an organ electromagnetic sensor configured to sense a magnetic field associated with said organ, and to couple with a computing device, wherein said computing device is configured to:
receive a magnetic field data associated with said organ from said organ electromagnetic sensor;
translate said magnetic field data associated with said organ to at least one electrical current vector associated with said organ, wherein said at least one electrical current vector is expressed in Ampere units or equivalent units of current measurement;
localize said at least one electrical current vector to a location on said organ associated with said received magnetic field data; and
register said at least one electrical current vector to an image of said organ by overlaying a visual representation of said at least one electrical current vector onto the image of said organ at a location on said image of said organ corresponding to a location on said organ to which said at least one electrical current vector was localized; and
generate an electrical current density map of said organ for use in evaluating said organ based on said at least one electrical current vector.

### Claim 2 (depends on 1)

The system of claim 1, wherein said evaluation of said organ is non-invasive.

### Claim 3 (depends on 1)

The system of claim 1, wherein said organ is a heart.

### Claim 4 (depends on 3)

The system of claim 3, wherein said computing device is further configured to identify and define an arrhythmia.

### Claim 5 (depends on 4)

The system of claim 4, wherein said computing device is further configured to identify an arrhythmogenic focus in said heart.

### Claim 6 (depends on 1)

The system of claim 1, wherein said current density map comprises one or more colored areas each corresponding to a current density associated with each of said colored areas.

### Claim 7 (depends on 1)

The system of claim 1, wherein said organ is a brain.

### Claim 8 (depends on 7)

The system of claim 7, wherein said computing device is further configured to identify an ischemic focus in said brain.

### Claim 9 (depends on 1)

The system of claim 1, wherein said computing device is further configured to receive said image of said organ from a radiographic imaging system.

### Claim 10 (depends on 9)

The system of claim 9, wherein said radiographic imaging system comprises a fluoroscope.

### Claim 11 (depends on 9)

The system of claim 9, wherein said imaging system comprises a computer tomography system.

### Claim 12 (depends on 1)

The system of claim 1, wherein said image is a three dimensional image.

### Claim 13 (depends on 12)

The system of claim 12, wherein said three dimensional image is generated from two or more two dimensional images.

### Claim 14 (depends on 1)

The system of claim 1, wherein said computing device is further configured to receive demographic data associated with said individual.

### Claim 15 (depends on 14)

The system of claim 14, wherein said demographic data comprises one or more of age, race, gender, and medical history of said individual.

### Claim 16 (depends on 15)

The system of claim 15, wherein said received demographic data associated with said individual is used to identify a three dimensional image of an organ of a different individual, wherein the demographic data associated with said individual and demographic data associated with said different individual are essentially identical in one or more of said age, said race, said gender, and said medical history.

### Claim 17 (depends on 15)

The system of claim 15, wherein said three dimensional image of an organ comprises an image of an organ of said different individual.

### Claim 18 (depends on 1)

The system of claim 1, wherein said computing device is further configured to receive biometric data associated with said individual.

### Claim 19 (depends on 18)

The system of claim 18, wherein said biometric data comprises one or more of heart rate, blood pressure, and temperature of said individual, and wherein said computing device is further configured to generate an evaluation of said organ comprising said electrical current vector map and said biometric data.