# US 9,433,214 B2 · Active compounds combination containing fluopyram Bacillus and biologically control agent > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,433,214 B2 - Document ID: US9433214B2 - Status: Granted - Kind: B2 - Application number: 14/373,916 - Filed: 2013-01-22 - Published: 2014-12-11 - Granted: 2016-09-06 - Earliest claimed: 2012-01-25 - Assignees: Bayer Intellectual Property GmbH - Applicants: Bayer Intellectual Property GmbH; Bayer Cropscience AG - Inventors: Elke Hellwege; Heike Hungenberg - Web page: https://patentgrep.com/patent/US9433214B2 ## CPC - A01N 43/40: six-membered rings - A01N 65/00: Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof (containing compounds of determined constitution A01N27/00 - A01N59/00) - A01N 63/22: Bacillus - A01N 63/30: Microbial fungi; Substances produced thereby or obtained therefrom - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS ## Abstract The present invention relates to active compound combinations and compostions for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (A) Fluopyram, (B) a spore-forming bacterium of the genera Bacillus, selected from Bacillus firmus, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilis strain QST713, and (C) at least one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary to metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed. ## Claims ### Claim 1 An active compound combination comprising: (A) Fluopyram, (B) a spore-forming bacterium of the general Bacillus, selected from the group consisting of Bacillus firmus, and (C) at least one biological control agent selected from the group consisting of (C1.27) Bacillus thuringiensis and (C2.9) Metarhizium anisopliae, wherein A, B and C together exhibits a synergistic effect. ### Claim 2 (depends on 1) The active compound combination according to claim 1, wherein the combination has fungicidal and nematicidal and optionally insecticidal activity. ### Claim 3 (depends on 1) The active compound combination according to claim 1, wherein the spore-forming bacterium (B) of the genera Bacillus is (B1) Bacillus firmus strain CNCM I-1582. ### Claim 4 (depends on 1) The active compound combination according to claim 1, wherein (C) is selected from the group consisting of (C1) (C1.27d) Bacillus thuringiensis subsp. tenebrionis strain NB 176 and (C2.9) Metarhizium anisopliae, strain F52 (DSM 3884, ATTC 90448) or var. acridum isolate IMI 330189/ARSEF 7486. ### Claim 5 (depends on 1) A composition comprising the active compound combination according to claim 1 and further comprising at least one of an auxiliary, solvent, carrier, surfactant and/or extender. ### Claim 6 (depends on 1) A method for controlling insects, nematodes or phytopathogens comprising applying the active compound combination according to claim 1 to seed, a plant, to fruit of a plant and/or to soil on which a plant grows and/or will grow. ### Claim 7 (depends on 6) The method according to claim 6, wherein the plant, the fruit of the plant and/or the soil on which the plant grows and/or will grow is treated. ### Claim 8 (depends on 6) The method according to claim 6, wherein, in treatment of leaves, from 0.01 to 10 000 g/ha is applied and in the treatment of seed, from 2 to 200 g per 100 kg of seed is applied. ### Claim 9 (depends on 6) The method according to claim 6, comprising treating a, seed of a transgenic plant and/or a transgenic plant with the active compound combination. ### Claim 10 (depends on 1) Seed treated with the active compound combination according to claim 1. ### Claim 11 (depends on 1) A method of treating a plant comprising applying to seed, a plant, to fruit of a plant and/or to soil on which a plant grows and/or will grow the active compound combination according to claim 1 for improvement of plant properties comprising one or more of better growth or increased harvest yields or a better developed root system or a larger leaf area or greener leaves or stronger shoots. ### Claim 12 (depends on 6) The method according to claim 6, wherein nematodes are controlled. ### Claim 13 (depends on 1) The combination according to claim 1, wherein the (C) at least one biological control agent comprises Metarhizium anisopliae strain F52 (DSM 3884, ATCC 90448). ### Claim 14 (depends on 1) The combination according to claim 1, wherein the (C) at least one biological control agent comprises (C1.27d) Bacillus thuringiensis subsp. tenebrionis strain NB 176. ### Claim 15 (depends on 1) The combination according to claim 1, wherein the only active components in the combination are actives (A), (B) and (C). ### Claim 16 (depends on 2) The combination according to claim 2, wherein the (C) at least one biological control agent comprises Metarhizium anisopliae strain F52. ### Claim 17 (depends on 2) The combination according to claim 2, wherein the (C) at least one biological control agent comprises Bacillus thuringiensis subsp. tenebrionis.