US 9,429,575 B2 · DNA aptamer specifically binding to EN2 (engrailed-2) and use thereof

Abstract

The present invention relates to a DNA aptamer specifically binding to EN2 (Engrailed-2), a biosensor for diagnosing prostate cancer having the same, and a method of diagnosing prostate cancer. A strong binding force and excellent specificity of the DNA aptamer of the present invention and the biosensor using the same with respect to EN2 proteins were identified. A detection specificity problem of a prostate-specific antigen (PSA) test used for prostate cancer diagnosis of the related art was addressed. Therefore, the present invention is expected to be beneficially used for early diagnosis of prostate cancer more effectively and increase diagnostic accuracy.

Claims5

Dependent claims

A DNA aptamer specifically binding to EN2 (Engrailed-2) and having a nucleotide sequence selected from among SEQ ID NOs 5 to 10.

Dependencies are inferred from the claim text.

Facts

Application

14/933,113Filed 5 Nov 2015

Priority

KR 10-2014-018812424 Dec 2014

Published

US 2016/0187342 A130 Jun 2016

Granted

30 Aug 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

G01N 33/57555
For cancer: of the prostate
C12N 15/115
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: aptamers, i.e. nucleic acids binding a…
C12N 2310/16
Type of nucleic acid: aptamers
C12N 2320/10
Applications; Uses: in screening processes

DNA aptamer specifically binding to EN2 (engrailed-2) and use thereof

Life of this patent

DNA aptamer specifically binding to EN2 (engrailed-2) and use thereof

Life of this patent

Abstract

Claims5