Apparatus and method for processing a sample
Assignee3M Innovative Properties Company
InventorsJon A. Kirschhoffer, Andrew H. Tilstra, Wensheng Xia
Life of this patent
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Abstract
An apparatus and an assembly for processing a sample are provided. The apparatus comprises a plurality of spaced-apart reservoirs, a plurality of channels, and a plurality of outlets, each outlet comprising an effluent discharge opening. The apparatus forms a plurality of flow paths, each flow path comprising a reservoir, a channel, and an outlet. An analyte capture element can be slideably engaged in a channel in a position where it is in fluid communication with the flow path. The apparatus with the analyte capture element disposed in the flow path can be used to process a liquid sample. A method of detecting an analyte in the liquid sample is also provided.
Claims20
An assembly, comprising:
- an apparatus for processing a sample, the apparatus comprising:
- a body having a first end and a second end opposite the first end, the body comprising:
- a plurality of spaced-apart reservoirs in a linear array, each reservoir comprising a sample-receiving opening, the plurality of reservoirs comprising a first reservoir and a second reservoir adjacent the first reservoir;
- wherein the first reservoir has a first sample-receiving opening;
- a plurality of spaced-apart effluent discharge openings, each effluent discharge opening in fluid communication with one of the plurality of sample-receiving openings via a liquid flow path, the plurality of effluent discharge openings comprising a first effluent discharge opening;
- a plurality of liquid flow paths, the plurality of liquid flow paths comprising a first liquid flow path;
- wherein the first liquid flow path extends from the first sample-receiving opening to the first effluent discharge opening;
- wherein the first effluent discharge opening is in fluid communication with the first sample-receiving opening via the first liquid flow path;
- a plurality of channels, each channel intersecting one liquid flow path of the plurality of liquid flow paths, the plurality of channels comprising a first channel;
- wherein the first channel intersects the first liquid flow path;
- wherein each channel of the plurality of channels comprises a channel exit opening proximate the second end;
- wherein the first channel comprises a first channel exit opening;
- wherein each channel of the plurality of channels is dimensioned to receive an analyte capture element;
- and
- a plurality of spaced-apart outlets extending from the body;
- wherein each of the outlets comprises one of the channel exit openings;
- wherein the plurality of outlets includes a first outlet;
- wherein the first outlet comprises the first channel exit opening;
- wherein the second reservoir has a second sample-receiving opening and a second outlet having a second effluent discharge opening;
- and
- a waste receptacle operably coupled to the apparatus;
- wherein the waste receptacle comprises a plurality of spaced-apart chambers, wherein the plurality of spaced-apart chambers comprises:
- a first chamber having a first interior volume and a first drain;
- and
- a second chamber adjacent the first chamber, the second chamber having a second interior volume and a second drain;
- and
- an analyte capture element slideably engaged in one of the channels;
- wherein the first liquid flow path further extends from the first sample-receiving opening to the first drain, and a second liquid flow path extends from the second sample-receiving opening to the second drain;
- wherein a first shortest distance between the first effluent discharge opening and the second effluent discharge opening is shorter than a second shortest distance between the first drain and the second drain.
A method of detecting a presence or an absence of an analyte in a sample, the method comprising:
- providing a liquid sample and an apparatus comprising,
- a body having a first end and a second end opposite the first end, the body comprising:
- a plurality of spaced-apart reservoirs in a linear array, each reservoir comprising a sample-receiving opening, the plurality of reservoirs comprising a first reservoir and a second reservoir adjacent the first reservoir;
- wherein the first reservoir has a first sample-receiving opening;
- a plurality of spaced-apart effluent discharge openings, each effluent discharge opening in fluid communication with one of the plurality of sample-receiving openings via a liquid flow path, the plurality of effluent discharge openings comprising a first effluent discharge opening;
- a plurality of liquid flow paths, the plurality of liquid flow paths comprising a first liquid flow path;
- wherein the first liquid flow path extends from the first sample-receiving opening to the first effluent discharge opening;
- wherein the first effluent discharge opening is in fluid communication with the first sample-receiving opening via the first liquid flow path;
- a plurality of channels, each channel intersecting one liquid flow path of the plurality of liquid flow paths, the plurality of channels comprising a first channel;
- wherein the first channel intersects the first liquid flow path;
- wherein each channel of the plurality of channels comprises a channel exit opening proximate the second end;
- wherein the first channel comprises a first channel exit opening;
- wherein each channel of the plurality of channels is dimensioned to receive an analyte capture element;
- a plurality of spaced-apart outlets extending from the body;
- wherein each of the outlets comprises one of the channel exit openings;
- wherein the plurality of outlets includes a first outlet;
- wherein the first outlet comprises the first channel exit opening;
- and an analyte capture element;
- wherein the analyte capture element is movably engaged in the first channel at a location that is in fluid communication with the first liquid flow path;
- contacting the liquid sample with the analyte capture element;
- ejecting the analyte capture element from the channel;
- and
- detecting a presence or an absence of an analyte retained from the sample by the analyte capture element.
A kit, comprising:
- an apparatus comprising:
- a body having a first end and a second end opposite the first end, the body comprising:
- a plurality of spaced-apart reservoirs in a linear array, each reservoir comprising a sample-receiving opening proximate the first end, the plurality of reservoirs including a first reservoir with a first sample-receiving opening and a second reservoir with a second sample-receiving opening;
- a plurality of spaced-apart effluent discharge openings, each effluent discharge opening in fluid communication with one of the plurality of sample-receiving openings via a liquid flow path;
- a plurality of liquid flow paths, each liquid flow path extending from the sample-receiving opening of each of the plurality of reservoirs to one effluent discharge opening of the plurality of effluent discharge openings;
- wherein the one of the plurality of effluent discharge openings is in fluid communication with one of the plurality of sample-receiving openings via one of the plurality of liquid flow paths;
- wherein the plurality of effluent discharge openings includes a first effluent discharge opening and a second effluent discharge opening;
- a plurality of channels, each channel intersecting one of the liquid flow paths;
- wherein each channel comprises a channel exit opening proximate the second end;
- wherein each channel is dimensioned to receive an analyte capture element;
- a plurality of spaced-apart outlets extending from the body, each of the outlets comprising one of the channel exit openings;
- and
- a waste receptacle comprising a plurality of spaced-apart chambers, each chamber having an outlet-receiving opening, an interior volume, and a drain;
- wherein the plurality of spaced-apart chambers comprises:
- a first chamber having a first interior volume and a first drain;
- and
- a second chamber adjacent the list chamber, the second chamber having a second interior volume and a second drain;
- wherein, when the apparatus and the waste receptacle are operably coupled, at least a portion of a first outlet is disposed in the first interior volume forming a first liquid flow path extending from the first sample-receiving opening to the first drain, and at least a portion of a second outlet is disposed in the second interior volume forming a second liquid flow path extending from the second sample-receiving opening to the second drain;
- and
- wherein a first shortest distance between the first effluent discharge opening and the second effluent discharge opening is shorter than a second shortest distance between the first drain and the second drain.
Dependencies are inferred from the claim text.