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US 9,428,785 B2Granted
Cationic polymer based wired enzyme formulations for use in analyte sensors
AssigneeAbbott Diabetes Care Inc.
InventorsBenjamin J. Feldman, Tianmei Ouyang, Zenghe Liu
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Abstract
Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring.
Claims15
An analyte sensor assembly, comprising:
- an electrochemical sensor comprising:
- a substrate comprising a working electrode and a counter electrode or a counter/reference electrode;
- a sensing layer disposed on the working electrode, wherein the sensing layer comprises a glucose-responsive enzyme, a cationic polymer selected from the group consisting of polyallylamine (PAH), polyethyleneimine (PEI), poly(L-lysine) (PLL), or poly(L-arginine) (PLA), and a positively charged redox mediator non-covalently associated with the cationic polymer;
- and
- a transmitter unit operatively coupled to the electrochemical sensor to receive signals from the electrochemical sensor corresponding to an analyte level of a subject.
2 more elements
Dependencies are inferred from the claim text.