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US 9,428,748 B2Granted
Method of expanding hematopoietic stem cells
OwnerHong Gao, Zhenglun Zhuinventors
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Abstract
Described is a method of expanding hematopoietic stem or progenitor cells. The invention further includes a method of treating primary or secondary bone marrow failure syndrome.
Claims4
A method of expanding hematopoietic stem cells, the method comprising:
- providing hematopoietic stem cells,
- contacting the hematopoietic stem cells with a morpholino oligonucleotide that inhibits the expression of a VentX polypeptide, and
- culturing the thus contacted hematopoietic stem cells under conditions that allow expansion of the contacted hematopoietic stem cells, whereby expansion of the contacted hematopoietic stem cells is increased as compared to that of control hematopoietic stem cells not contacted with the morpholino oligonucleotide.
Dependencies are inferred from the claim text.