Bio-hybrid material, production method therefor, and stent
AssigneeNational Institute for Materials Science
InventorsTetsushi Taguchi, Makoto Sasaki, Yasuyuki Katada
Life of this patent
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Abstract
Provided is a bio-hybrid material that does not cause elution of nickel ions and has an excellent endothelialization ability, a production method therefor, and a stent. The bio-hybrid material (101) used includes an alloy part (11) free of Ni, an organic acid (12) having two or more active esters, and a cytokine (13). The alloy part (11) free of Ni forms an ester bond with the organic acid (12), and the organic acid (12) and the cytokine (13) are immobilized via an amide bond.
Claims19
A bio-hybrid material comprising:
- an alloy part free of Ni;
- an organic acid having three or more active ester groups;
- and
- a cytokine,
- wherein the alloy part free of Ni forms an ester bond with the organic acid through one of the three or more active ester groups of the organic acid, and the organic acid and the cytokine are immobilized via an amide bond through active ester groups free of the ester bond with the alloy part free of Ni among the three or more active ester groups of the organic acid.
A bio-hybrid material comprising:
- an alloy part free of Ni having a hydroxyl group on a surface;
- an organic acid having three or more active ester groups;
- and
- a cytokine,
- wherein the alloy part free of Ni forms an ester bond with the organic acid through one of the three or more active ester groups of the organic acid, and the organic acid and the cytokine are immobilized via an amide bond through active ester groups free of the ester bond with the ally part free of Ni among the three or more active ester groups of the organic acid.
A bio-hybrid material comprising:
- an alloy part free of Ni having a hydroxyl group on a surface;
- an organic acid having three or more succinimidyl ester groups;
- and
- a cytokine,
- wherein the alloy part free of Ni forms an ester bond with the organic acid through one of the three or more active ester groups of the organic acid, and the organic acid and the cytokine are immobilized via an amide bond through active ester groups free of the ester bond with the ally part free of Ni among the three or more active ester groups of the organic acid.
Dependencies are inferred from the claim text.