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US 9,428,586 B2Granted
Heparanase splice variant
AssigneeCompugen Ltd.
InventorsRonen Shemesh, Michal Ayalon-Soffer, Zurit Levine, Sergey Nemzer, Tomer Zekharya, Gad S. Cojocaru, Uri Barash, Neta Ilan, Israel Vlodavsky, Iris Hecht
Life of this patent
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Abstract
The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
Claims3
A monoclonal or polyclonal antibody comprising an antigen binding site that binds specifically to T5, with SEQ ID NO:
- 1, polypeptide, wherein said antibody binds to the known, wild type heparanase protein with a binding affinity that is at least 5 times lower than a binding affinity to T5, with SEQ ID NO:
- 1, wherein the antibody is secreted by 9c9 hybridoma deposited according to the provisions of the Budapest Treaty with the Health Protection Agency Culture Collections (Centre for Emergency Preparedness & Response, Porton Down, Salisbury SP4 OJG, United Kingdom), having a Accession Number:
- 10111101.
Dependencies are inferred from the claim text.