Antibody against the CSF-1R

An isolated, recombinant or purified antibody that specifically binds to human CSF-1R, wherein

• (i) it comprises:
• (a) a heavy-chain variable region being defined by the following formula
• FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
• wherein:
• FR1, FR2, FR3, and FR4 are each framework regions;
• CDR1, CDR2, and CDR3 are each complementarity determining regions;
• wherein:
• CDR1 has at least five consecutive amino acids of the sequence starting in position 45 and finishing in position 54 of SEQ ID NO:2, wherein said at least five consecutive amino acids include SEQ ID NO:11;
• CDR2 has at least five consecutive amino acids of the sequence starting in position 66 and finishing in position 87 of SEQ ID NO:2, wherein said at least five consecutive amino acids include SEQ ID NO:
• 12;
• and
• CDR3 has at least five consecutive amino acids of the sequence starting in position 117 and finishing in position 126 of SEQ ID NO:2, wherein said at least five consecutive amino acids include SEQ ID NO:13;
• and
• (b) a light-chain variable region being defined by the following formula
• FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
• wherein:
• FR1, FR2, FR3, and FR4 are each framework regions;
• CDR1, CDR2, and CDR3 are each complementarity determining regions;
• wherein:
• CDR1 has at least five consecutive amino acids of the sequence starting in position 44 and finishing in position 56 of SEQ ID NO:4, wherein said at least five consecutive amino acids include SEQ ID NO:
• 14;
• CDR2 has at least five consecutive amino acids of the sequence starting in position 66 and finishing in position 76 of SEQ ID NO:4, wherein said at least five consecutive amino acids include SEQ ID NO:15;
• and
• CDR3 has at least five consecutive amino acids of the sequence starting in position 109 and finishing in position 117 of SEQ ID NO:4, wherein said at least five consecutive amino acids include SEQ ID NO:16;
• and
• (ii) it has at least one of the following advantageous properties:
• it binds to one epitope located between position amino acids 20 to 41 of SEQ ID NO:29;
• it does not bind to an epitope located between position amino acids 42 to 90 of SEQ ID NO:29, and/or between position amino acids 91 to 104 of SEQ ID NO:29;
• it does not bind to an epitope located between position amino acids 105 to 199 of SEQ ID NO:29;
• and
• it does not bind to an epitope located between position amino acids 200 to 298 of SEQ ID NO:29.