Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies
AssigneeNovartis AG
InventorsFeng Cong, Seth Ettenberg, Felix Hartlepp, Ingo Klagge
Life of this patent
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Abstract
The present disclosure relates to antibodies targeting LRP6 and compositions and methods of use thereof.
Claims52
An antibody or fragment thereof that binds to a low density lipoprotein-related 6 (LRP6) wherein the antibody or fragment thereof comprises a heavy chain variable region CDR1 of SEQ ID NO:
- 1;
- a heavy chain variable region CDR2 of SEQ ID NO:
- 2;
- a heavy chain variable region CDR3 of SEQ ID NO:
- 3;
- a light chain variable region CDR1 of SEQ ID NO:
- 4;
- a light chain variable region CDR2 of SEQ ID NO:
- 5;
- and a light chain variable region CDR3 of SEQ ID NO:
- 6.
An isolated antibody or fragment thereof that binds to a β-propeller 1 (P1) domain of a low density lipoprotein-related protein 6 (LRP6), wherein the antibody or fragment thereof comprises a VH and VL pair selected from the group consisting of a VH comprising SEQ ID NO:
- 14 and a VL comprising SEQ ID NO:
- 13.
An antibody that binds to a low density lipoprotein-related 6 (LRP6) or fragment thereof comprising a heavy chain variable region CDR1 of SEQ ID NO:
- 7;
- a heavy chain variable region CDR2 of SEQ ID NO:
- 8;
- a heavy chain variable region CDR3 of SEQ ID NO:
- 9;
- a light chain variable region CDR1 of SEQ ID NO:
- 10;
- a light chain variable region CDR2 of SEQ ID NO:
- 11;
- and a light chain variable region CDR3 of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.