Antigen binding polypeptides
AssigneeArgen-X N.V.
InventorsTorsten Dreier, Christophe Frederic Jerome Blanchetot, Johannes Joseph Wilhelmus De Haard
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Abstract
The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire of species in the family Camelidae, and to antigen binding polypeptides obtained using this technology platform. In particular, the invention provides an antigen binding polypeptide comprising a VH domain and a VL domain, wherein at least one hypervariable loop or complementarity determining region (CDR) in the VH domain or the VL domain is obtained from a VH or VL domain of a species in the family Camelidae.
Claims28
A library of expression vectors comprising cDNA sequences encoding VH and VL domains of camelid conventional antibodies from a camelid actively immunized with a target antigen.
An expression vector comprising cDNA sequences encoding a VH and VL domain of a camelid conventional antibody from a camelid actively immunized with a target antigen.
A composition comprising an expression vector comprising a cDNA sequence encoding a camelid VH domain and an expression vector comprising a cDNA sequence encoding a camelid VL domain, wherein the camelid VH and VL domains are from a camelid actively immunized with a target antigen.
Dependencies are inferred from the claim text.