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US 9,428,578 B2Granted
Methods of treating anaemia
AssigneeKymab Limited
InventorJasper Rupert Clube
Life of this patent
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Abstract
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
Claims30
A method of treating or reducing the risk of anaemia in a human haemodialysis patient, the method comprising administering a trap, an antibody or an antibody fragment that binds specifically to BMP6 to the human haemodialysis patient,
- wherein the trap, antibody or antibody fragment comprises a human kappa chain constant region comprising a Val at position 84 shown in SEQ ID NO:
- 93 or a Cys at position 87 shown in SEQ ID NO:
- 9;
- and
- wherein
- (i) the human comprises a TMPRSS6 nucleotide sequence comprising a SNP rs855791;
- rs2543519;
- rs2235324;
- or rs1421312;
- and
- (ii) the human comprises and expresses an IGKC1*01 human kappa chain constant region gene segment, or the human expresses antibodies comprising human kappa chain constant regions comprising a Val corresponding to position 84 shown in SEQ ID NO:
- 93 or a Cys at position 87 shown in SEQ ID NO:
- 93.
10 more elements
A method of treating or reducing the risk of anaemia in a human haemodialysis patient in need thereof, the improvement comprising:
- administering to said patient an anti-BMP6 trap, antibody or antibody fragment to specifically bind in the patient a BMP6;
- wherein the trap, antibody, or antibody fragment comprises a human kappa chain constant region comprising a Val at position 84 shown in SEQ ID NO:
- 93 or a Cys at position 87 shown in SEQ ID NO:
- 93, and
- wherein said patient comprises:
- (i) TMPRSS6 nucleotide sequence comprising a SNP rs855791;
- rs2543519;
- rs2235324;
- or rs1421312;
- and
- (ii) a constant region gene segment encoding said selected constant region;
- or wherein said patient expresses antibodies comprising said selected constant region.
9 more elements
Dependencies are inferred from the claim text.