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US 9,428,577 B2Granted
Platelet-derived growth factor B specific antibodies and compositions and uses thereof
AssigneePfizer Inc.
InventorsRobert Arch, Gregory Carven, Jun Kuai, Lydia Mosyak, Shinji Ogawa, Dirk Ponsel, Robert Rauchenberger
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Abstract
The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to PDGF-B. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of PDGF-B mediated diseases, disorders or conditions.
Claims7
An isolated antibody, or antigen-binding fragment thereof, that specifically binds PDGF-B and comprises:
- a VH comprising the CDR-H1 amino acid sequence of SEQ ID NO:7, the CDR-H2 amino acid sequence of SEQ ID NO:8, and the CDR-H3 amino acid sequence of SEQ ID NO:
- 9;
- and
- a VL comprising the CDR-L1 amino acid sequence of SEQ ID NO:10, the CDR-L2 amino acid sequence of SEQ ID NO:11, and the CDR-L3 amino acid sequence of SEQ ID NO:12.
1 more element
Dependencies are inferred from the claim text.