Back to results
US 9,428,569 B2Granted
Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters
AssigneeBaylor College of Medicine
InventorsDavid Spencer, Priyadharshini Narayanan
Life of this patent
Estimating the term…
Abstract
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
Claims17
A composition comprising a nucleic acid comprising a promoter operably linked to a polynucleotide that encodes a chimeric protein, wherein the chimeric protein comprises:
- (i) a membrane targeting region;
- (ii) a multimeric ligand-binding region;
- (iii) a cytoplasmic CD40 polypeptide region lacking the extracellular domain;
- and
- (iv) a truncated MyD88 polypeptide lacking the TIR domain comprising the amino acid sequence SEQ ID NO:
- 6.
3 more elements
Dependencies are inferred from the claim text.