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US 9,428,561 B2Granted
Polypeptide-polymer conjugates and methods of use thereof
AssigneeThe Regents of the University of California
InventorsKevin Edward Healy, Samuel T. Wall, Krishanu Saha, David V. Schaffer
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Abstract
The present invention provides polypeptide-polymer conjugates. A subject polypeptide-polymer conjugate is useful in a variety of applications, which are also provided.
Claims23
A conjugate comprising:
- a) a biologically active polypeptide having a molecular weight of from about 5 kDa to about 2000 kDa, and wherein the biologically active polypeptide is:
- i) a receptor;
- or ii) a ligand for a receptor;
- and
- b) a biocompatible polymer having a molecular weight of at least about 50,000 Daltons,
- wherein the polypeptide is covalently linked to the polymer directly or via a linker, and wherein the molar ratio of the biologically active polypeptide to the polymer is at least about 10:1.
3 more elements
Dependencies are inferred from the claim text.