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US 9,428,560 B2Granted
Protein comprising truncated form of extracellular region protein of Frizzled 2, and pharmaceutical composition for treating bone diseases which comprises said protein
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsMakoto Kakitani, Kengo Yamawaki
Life of this patent
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Abstract
The present invention provides a protein comprising a truncated form of an extracellular region protein of Frizzled 2, which has higher secretion activity than that of a known protein comprising an extralellular cysteine-rich domain of Frizzled 2 in a production cell and bone mass-increasing activity higher than or equal to that of the known protein, or DNA encoding said protein.
Claims11
A fusion protein of
- (a) a protein comprising amino acids from the amino acid Q at position 1 of the N-terminal to any one amino acid of A at position 153, G at position 154, G at position 155, T at position 156, P at position 157, G at position 158, G at position 159, P at position 160, G at position 161, G at position 162, G at position 163, G at position 164, A at position 165, P at position 166, P at position 167, R at position 168, Y at position 169, A at position 170, T at position 171, L at position 172, Eat position 173, H at position 174, or P at position 175 of the amino acid sequence of SEQ ID NO:1;
- and
- (b) a mammal-derived immunoglobulin Fc protein or a variant of the mammal-derived immunoglobulin Fc protein.
A fusion protein comprising the amino acid sequence of any one of SEQ ID NOs:
- 72 to 94.
A DNA consisting of the nucleotide sequence of any one of SEQ ID NOs:
- 42 to 64.
Dependencies are inferred from the claim text.