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US 9,428,553 B2Granted
Meditopes and meditope-binding antibodies and uses thereof
AssigneeCity of Hope
InventorsJohn C. Williams, Cindy Zer, Krzysztof Bzymek, Kendra Nicole Avery
Life of this patent
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Abstract
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
Claims15
A peptide having the formula:
- R1A—L1A-R2A
- wherein:
- R1A is a meditope comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1, 2, 16-18, 23, 29, 31, 32, 36, 39, 42, 43, 45, 46, 51, 52, 54, and 55;
- L1A is a linker of about 2 Å to about 100 Å in length;
- and
- R2A is a peptidyl kappa light chain binding moiety that binds to the peptidyl kappa light chain of the meditope-enabled antibody without decreasing antigen binding of the meditope-enabled antibody, wherein R2A comprises the sequence:
- X13-VTI-X14-VN-X15-IFADG-X16-IQTA-X17-F-X18-GTFEEATAEAYR-X19-AALLA-X20-VNGEYTADLEDGGNHMNI-X21-FAG-R3 (IG) (SEQ ID NO:
- 184),
- wherein:
- X13 is Glu or null;
- X14 is Arg, Lys, or a conjugated amino acid;
- X15 is Lys, a conjugated amino acid, or Leu;
- X16 is Lys or a conjugated amino acid;
- X17 is Glu or Pro;
- X18 is Pro, Arg, Lys, or a conjugated amino acid;
- X19 is Tyr or Trp;
- X20 is Arg, Lys, or conjugated amino acid;
- X21 is Lys or a conjugated amino acid;
- and
- R3 is null or a conjugated peptidyl moiety.
18 more elements
Dependencies are inferred from the claim text.