Stem cell mobilization and tissue repair and regeneration
AssigneeWellstat Therapeutics Corporation
InventorsIrena Tsyrlova, Fawn Petty, Reid W. von Borstel, Julian Reading, Jiong Pei, Joel Saydoff
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Abstract
Stem cells are mobilized from bone marrow by administering an amount of Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO: 2) or Phe-Ala-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO: 3) effective to mobilize the stem cells. This is useful for promoting bodily tissue regeneration in a patient in need of tissue regeneration treatment. Alternatively, the mobilized stem cells can be collected for transplant.
Claims18
An oligopeptide having the sequence Phe-Xaa-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO:
- 1), wherein Xaa is Pro or Ala.
A pharmaceutical composition comprising a compound (SEQ ID NO:
- 1) for mobilizing stem cells from bone marrow of a subject.
A method of mobilizing stem cells from bone marrow of a subject, comprising administering to the subject an amount of compound (SEQ ID NO:
- 1) effective to mobilize the stem cells.
Dependencies are inferred from the claim text.