Antimicrobial peptides
AssigneeThe University of Manchester
InventorsMathew Upton, Stephanie Sandiford
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Abstract
The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by biofilm-forming bacteria and especially biofilm-forming Staphyloccocal bacteria. The invention includes the nucleic acids encoding the polypeptides, methods of treating bacterial infections, medical devices or implants or prosthetics impregnated with, covered or coated in the polypeptides, and means of delivery of the peptide to the oral cavity.
Claims18
An isolated or recombinant polypeptide comprising a peptide sequence QSFEWIYKQIKKLWA [SEQ ID NO:1] or a variant thereof having at least 90% identity to SEQ ID NO:1, wherein the isolated or recombinant polypeptide is bactericidal.
An isolated or recombinant polypeptide comprising a peptide sequence QSFEWIYKQIKKLWA [SEQ ID NO:1] or a variant thereof having at least 90% identity to SEQ ID NO:1, wherein the isolated or recombinant polypeptide has an inhibitory effect on biofilm formation by a biofilm-producing bacterium.
Dependencies are inferred from the claim text.