Peptides and methods and uses thereof for preventing retinal disorders
AssigneeThe Governing Council of the University of Toronto
InventorPaulo Koeberle
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Abstract
The present disclosure relates to methods and uses of C-terminal peptides for inhibiting neuronal cell death or dysfunction, such as retinal ganglion cell death or dysfunction, treating retinal degenerative disorders, stroke, CNS and PNS insults. The disclosure also relates to the C-terminal peptides, fusion proteins and compositions thereof.
Claims12
A method for inhibiting neuronal cell death in an animal or cell in need thereof comprising administering at least one C-terminal peptide, wherein the C-terminal peptide comprises the amino acid sequence as shown in SEQ ID NOs:1-6, 8 or 9 or a conservatively substituted functional variant thereof;
- wherein the C-terminal peptide is 9 to 12 amino acids in lenqth.
Dependencies are inferred from the claim text.