Lupane triterpenoid derivatives and pharmaceutical use thereof

A compound of formula (I), or a pharmaceutically acceptable salt thereof,

• wherein:
• R1 is independently H,
• X is independently methylene, or carbonyl;
• L is independently a direct bond, —NR4—, —(CH2)r-,
• Y is independently a direct bond, —NR4—, —NR4CH2—,
• —CH2—, —C(═O)—, —CH(CH3)—, or —C(CH3)2—;
• Ar1is independently substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• when substituted, the substituents are one, two or three groups independently selected from the group consisting of:
• halo, alkyl, alkoxy, haloalkyl, haloalkoxy, amino, aminoalkyl, hydroxyalkyl, thioalkyl, —NHC(O)NH2, —NHC(O)NH(R3), —OH, —NO2, —SH, —CN, —C(O)OH, —R3C(O)OH, HOOC—R3—C(O)—, —C(O)O—R3, —C(O)NH2, —C(O)NH(R3), —C(O)N(R3)2, —(CH2)rCONH2, —(CH2)rCONHR3, and —(CH2)rCON(R3)2;
• Ar2 is independently substituted or unsubstituted heteroaryl;
• when substituted, the substituents are one, two or three groups independently selected from the group consisting of:
• halo, haloalkyl, haloalkoxy, amino, —OH, —NO2, —SH, —(CH2)rS(═O)CH3, —(CH2)rS(═O)2CH3, —CN, —C(O)OH, —C(O)O—R3, —C(O)NH2, —C(O)NH(R3), —C(O)N(R3)2, —(CH2)rCONH2, —(CH2)rCONHR3, —(CH2)rCON(R3)2, aminoalkyl, hydroxyalkyl, alkyl, alkynyl, alkoxy, cycloalkylalkyl, and heterocycloalkylalkyl;
• R3 is independently alkyl, or two R3 groups together with the nitrogen atom to which they are attached, form a 3- to 7-membered heterocycloalkyl ring;
• R4 is independently hydrogen, alkyl, cycloalkylalkyl, heterocycloalkylalkyl, aminoalkyl, hydroxyalkyl, —(CH2)rS(═O)CH3, —(CH2)rS(═O)2CH3, —C(O)O—R3, —C(O)NH2, —C(O)NH(R3), —C(O)N(R3)2, —(CH2)rCONH2, —(CH2)rCONHR3, or —(CH2)rCON(R3)2;
• and
• r is an integer from 1 to 8.