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US 9,428,537 B2Granted
tRNA derived small RNAs (tsRNAs) involved in cell viability
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMark A. Kay, Hak kyun Kim, Shengchun Wang
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Abstract
The present invention features compositions and methods relating to tRNA-derived small RNAs (tsRNAs). Provided herein are oligonucleotide compositions that are complementary to tsRNAs, in particular leuCAGtsRNA, and methods of using the oligonucleotides for the regulation of respective tsRNA. Further provided are methods of inducing apoptosis through the inhibition of leuCAGtsRNA.
Claims12
An oligonucleotide that is complementary to a tRNA-derived small RNA (tsRNA), wherein the oligonucleotide is selected from the group consisting of:
- (a) tGTcAGgAgTggGaT;
- (SEQ ID NO:
- 2)
- and
- (b) GGTGtcaggagtggGATT,
- (SEQ ID NO:
- 11)
- wherein uppercase letters represent locked nucleic acids and lowercase letters represent unmodified nucleic acids.
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