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US 9,428,536 B2Granted
Immunostimulatory G, U-containing oligoribonucleotides
AssigneeZoetis Belgium S.A.
InventorsGrayson B. Lipford, Stefan Bauer, Hermann Wagner
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Abstract
Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.
Claims7
A synthetic G,U-rich immunostimulatory RNA oligomer which is 15-40 nucleotides long comprising multiples of 5′-GUUGB-3′, wherein B represents U, G, or C;
- wherein the multiples are linked through a single intervening linking nucleoside, which is selected from the group consisting of G and U.
Dependencies are inferred from the claim text.