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US 9,428,533 B2Granted
Inhibitors of advanced glycation end products
AssigneeNephroGenex, Inc.
InventorsRaja G. Khalifah, Roger E. Marti
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds of the formula, wherein A, B, G, R2, R6, and X are defined herein, pharmaceutical compositions of the same, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.
Claims20
A compound of the formula,
- or a pharmaceutically acceptable salt thereof, wherein
- X is N or N—O;
- G is —H;
- A is of the formula,
- wherein
- Y is N or N-oxide;
- and
- ring C is:
- (i) monocyclic;
- (ii) saturated;
- and
- (iii) contains 1 or 2 total heteroatoms, and 5 or 6 total atoms, wherein
- the remaining heteroatom moiety is O, S, or NRN1, and the carbon atoms are each optionally substituted with one or two RC wherein
- RN1 is —H, -oxide, —(C1-C6)alkyl, —(C2-C6)alkenyl, —(C1-C6)alkynyl, —(C1-C6)haloalkyl, or —(C1-C6)alkanoyl;
- each RC is independently —Z1-M-Z2—RZ, wherein
- Z1, M and Z2 are absent, and
- RZ is —H, —(C1-C6)alkyl, —(C2-C6)alkenyl, —(C1-C6)alkynyl, or —(C1-C6)haloalkyl, —(C3-C8)cycloalkyl, —(C1-C6)alkylaryl, -heterocycle, -aryl, or -heteroaryl;
- B is imidazolyl wherein each carbon atom is substituted by R3, wherein
- each R3 is independently RZ3, wherein
- RZ3 is —H, —(C1-C6)alkyl, —(C1-C6)haloalkyl, —(C3-C8)cycloalkyl, —(C1-C6)alkylaryl, -heterocycle, -aryl, or -heteroaryl;
- and
- R2, and R6 are independently —H, -halogen, —NO2, —CN, or RZ6 wherein RZ6 is —(C1-C6)alkyl or —(C1-C6)haloalkyl.
19 more elements
Dependencies are inferred from the claim text.