Bromodomain inhibitors

A compound of formula (I) or a pharmaceutically acceptable salt thereof

• wherein
• R1 is C1-C3 alkyl or C1-C3 haloalkyl;
• R2 is H;
• R3 is —O—C1-C6 alkyl, —OCD2CH3, or —OCD2CD3;
• Y1 is N or CR4, wherein R4 is H, C1-C3 alkyl, or C1-C3 haloalkyl;
• A2 is CR5, and A1, A3, and A4 are CR6;
• or
• A2 is CR5, A1 and A3 are CR6, and A4 is N;
• R5 is —N(R5d)—C1-C6 alkylenyl-R5a, —N(R5d)C(O)—C1-C6 alkylenyl-R5b, —N(R5d)SO2—C1-C6 alkylellyl-R5c, —N(R5d)C(O)N(R5d)-G1, —N(R5d)C(O)N(R5d)—C1-C6 alkylenyl-R5a, —N(R5d)SO2N(R5d)—C1-C6 alkylenyl-R5a, —C(O)N(R5d)—C1-C6 alkylenyl-R5a, or —SO2N(R5d)—C1-C6 alkylenyl-R5a, wherein
• R5a, at each occurrence, is independently G1, —OR5aa, —OC(O)R5dd, —SR5aa, —S(O)R5aa, —SO2R5aa, —SO2NR5bbR5cc, —NR5bbR5cc, —NR5bbC(O)R5dd, —NR5bbSO2R5dd, —NR5bbC(O)OR5dd, —NR5bbC(O)NR5bbR5cc, —NR5bbSO2NR5bbR5cc, —C(O)R5aa, —C(O)OR5aa, or —C(O)NR5bbR5cc,
• R5b is G1, —OR5aa, —OC(O)R5dd, —SR5aa, —S(O)R5aa, —SO2R5aa, —SO2NR5bbR5cc, —N(R5bb)(G1), —NR5bb—(C1-C6 alkylenyl)-G1, —NR5bbC(O)R5dd, —NR5bbSO2R5dd, —NR5bbC(O)OG1, —NR5bbC(O)O—(C1-C6 alkylenyl)-G1, —NR5bbC(O)NR5bbR5cc, —NR5bbSO2NR5bbR5cc, —C(O)R5aa, —C(O)OR5aa, or —C(O)NR5bbR5cc,
• R5c is —OR5aa, —OC(O)R5dd, —SR5aa, —S(O)R5aa —SO2R5aa, —SO2NR5bbR5cc, —NR5bbR5cc, —NR5bbC(O)R5dd, —NR5bbSO2R5dd, —NR5bbC(O)OR5dd, —NR5bbC(O)NR5bbR5cc, —NR5bbSO2NR5bbR5cc, —C(O)R5aa, —C(O)OG1, —C(O)O—(C1-C6 alkylenyl)-G1, or —C(O)NR5bbR5cc,
• R5d, at each occurrence, is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, G1, —OR5aa, —OC(O)R5dd, —SR5aa, —S(O)R5aa, —SO2R5aa, —SO2NR5bbR5cc, —NR5bbR5cc, —NR5bbC(O)R5dd, —NR5bbSO2R5dd, —NR5bbC(O)OR5dd, —NR5bbC(O)NR5bbR5cc, —NR5bbSO2NR5bbR5cc, —C(O)R5aa, —C(O)OR5aa, —C(O)NR5bbR5cc, —(C1-C6 alkylenyl)-G1, —(C1-C6 alkylenyl)-OR5aa, —(C1-C6 alkylenyl)-OC(O)R5dd, —(C1-C6 alkylenyl)-SR5aa, —(C1-C6 alkylenyl)-S(O)R5aa, —(C1-C6 alkylenyl)-SO2R5aa, —(C1-C6 alkylenyl)-SO2NR5bbR5cc, —(C1-C6 alkylenyl)—NR5bbR5cc, —(C1-C6 alkylenyl)-NR5bbC(O)R5dd, —(C1-C6 alkylenyl)-NR5bbSO2R5dd, —(C1-C6 alkylenyl)-NR5bbC(O)OR5dd, —(C1-C6 alkylenyl)-NR5bbC(O)NR5bbR5cc, —(C1-C6 alkylenyl)-NR5bbSO2NR5bbR5cc, —(C1-C6 alkylenyl)-C(O)R5aa, —(C1-C6 alkylenyl)-C(O)OR5aa, or —(C1-C6 alkylenyl)-C(O)NR5bbR5cc;
• R6 is H, C1-C6 alkyl, halogen, C1-C6 haloalkyl, or —CN;
• R5aa, R5bb, and R5cc, at each occurrence, are each independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, G1, or —(C1-C6 alkylenyl)-G1;
• R5dd, at each occurrence, is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, G1, or —(C1-C6 alkylenyl)-G1;
• G1, at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 R1g groups,
• Y2 is -L-G2;
• wherein
• L is O or N(Rx) wherein Rx is H or C1-C6 alkyl;
• G2 is aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 R2g groups;
• R1g and R2g, at each occurrence, are each independently oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, C1-C6 haloalkyl, —CN, NO2, —ORz1, —OC(O)Rz2, —OC(O)NRz3Rz4, —SRz1, —S(O)2Rz1, —S(O)2NRz3Rz4, —C(O)Rz1, —C(O)ORz1, —C(O)NRz3Rz4, —NRz3Rz4, —N(Rz3)C(O)Rz2, —N(Rz3)S(O)2Rz2, —N(Rz3)C(O)O(Rz2), —N(Rz3)C(O)NRz3Rz4, —N(Rz3)S(O)2NRz3Rz4, G3, —(C1-C6 alkylenyl)-CN, —(C1-C6 alkylenyl)-ORz1, —(C1-C6 alkylenyl)-OC(O)Rz2, —(C1-C6 alkylenyl)-OC(O)NRz3Rz4, —(C1-C6 alkylenyl)-S(O)2Rz1, —(C1-C6 alkylenyl)-S(O)2NRz3Rz4, —(C1-C6 alkylenyl)-C(O)Rz1, —(C1-C6 alkylenyl)-C(O)ORz1, —(C1-C6 alkylenyl)-C(O)NRz3Rz4, —(C1-C6 alkylenyl)—NRz3Rz4, —(C1-C6 alkylenyl)—N(Rz3)C(O)Rz2, —(C1-C6 alkylenyl)-N(Rz3)S(O)2Rz2, —(C1-C6 alkylenyl)-N(Rz3)C(O)O(Rz2), —(C1-C6 alkylenyl)-N(Rz3)C(O)NRz3Rz4, —(C1-C6 alkylenyl)-N(Rz3)S(O)2NRz3Rz4, —(C1-C6 alkylenyl)-CN, or —(C1-C6 alkylenyl)-G3;
• Rz1, Rz3, and Rz4, at each occurrence, are each independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, G3, or —C1-C6 alkylenyl-G3;
• Rz2, at each occurrence, is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, G3, or —C1-C6 alkylenyl-G3;
• G3 is aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 R3g groups,
• R3g, at each occurrence, is independently oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, C1-C6 haloalkyl, —CN, NO2, —ORa, —OC(O)Rb, —OC(O)NRcRd, —SRa, —S(O)2Ra, —S(O)2NRcRd, —C(O)Ra, —C(O)ORa, —C(O)NRcRd, —NRcRd, —N(Rc)C(O)Rb, —N(Rc)S(O)2Rb, —N(Rc)C(O)O(Rb), —N(Rc)C(O)NRcRd, —N(Rc)S(O)2NRcRd, —(C1-C6 alkylenyl)-CN, —(C1-C6 alkylenyl)-ORa, —(C1-C6 alkylenyl)-OC(O)Rb, —(C1-C6 alkylenyl)-OC(O)NRcRd, —(C1-C6 alkylenyl)-S(O)2Ra, —(C1-C6 alkylenyl)-S(O)2NRcRd, —(C1-C6 alkylenyl)-C(O)Ra, —(C1-C6 alkylenyl)-C(O)ORa, —(C1-C6 alkylenyl)-C(O)NRcRd, —(C1-C6 alkylenyl)—NRcRd, —(C1-C6 alkylenyl)-N(Rc)C(O)Rb, —(C1-C6 alkylenyl)-N(Rc)S(O)2Rb, —(C1-C6 alkylenyl)-N(Rc)C(O)O(Rb), —(C1-C6 alkylenyl)-N(Rc)C(O)NRcRd, —(C1-C6 alkylenyl)-N(Rc)S(O)2NRcRd, or —(C1-C6 alkylenyl)-CN;
• Ra, Rc, and Rd, at each occurrence, are each independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C1-C6 haloalkyl, and
• Rb, at each occurrence, is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C1-C6 haloalkyl.