Compounds for the treatment of malaria

A compound according to Formula (I):

• wherein a and b are independently 0, 1, or 2;
• c is 0, 1, 2, 3, or 4;
• R1 is hydrogen, C1-C6 alkyl, C2-C9 heteroaryl, C3-C10 carbocyclyl C1-C6 alkyl, C6-C10 aryl C1-C6 alkyl, C2-C9 heteroaryl C1-C6 alkyl, —C(O)NR7R8, —C(O)OR9, —C(O)R10, or —S(O)2R11;
• each R2 is independently hydroxyl, halogen, or —OR12;
• R3 is hydrogen or C1-C6 alkyl;
• R4 is hydrogen or C1-C6 alkyl;
• R5 is C1-C6 alkyl, or —(CH2)nX1R13, or R5 and R6 together with the carbon and nitrogen atoms to which they are respectively attached, combine to form a 5-8-membered heterocycle;
• R6 is hydrogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C10 carbocyclyl C1-C6 alkyl, C6-C10 aryl C1-C6 alkyl, C2-C9 heteroaryl C1-C6 alkyl, C2-C9 heterocyclyl C1-C6 alkyl, N-protecting group, —C(O)R15, —C(O)NR16R17, or —S(O)2R18;
• R7 is hydrogen or C1-C6 alkyl;
• R8 is C6-C10 aryl, C2-C9 heteroaryl, C2-C9 heterocyclyl, or C3-C10 carbocyclyl;
• R9 is C1-C6 alkyl or C6-C10 aryl;
• R10 is C1-C6 alkyl, C6-C10 aryl, C2-C9 heterocyclyl, C6-C10 aryl C1-C6 alkyl, or C2-C9 heteroaryl C1-C6 alkyl;
• R11 is C1-C6 alkyl, C6-C10 aryl, or C6-C10 aryl C1-C6 alkyl;
• each R12 is C1-C6 alkyl or C1-C6 acyl;
• n is 1, 2, 3, 4, 5, or 6;
• X1 is absent, O, or NR14;
• R13 is hydrogen, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 perfluoroalkyl, C1-C6 acyl, C6-C10 aryl C1-C6 alkyl, an O- or N-protecting group, or R13 and R14 combine to form a 5-8-membered heterocycle;
• R14 is hydrogen or C1-C6 alkyl;
• R15 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 heteroalkyl, C3-C10 carbocyclyl, C2-C9 heterocyclyl, C6-C10 aryl, C6-C10 aryl C1-C6 alkyl;
• R16 and R17 are independently hydrogen, C1-C6 alkyl, or C6-C10 aryl;
• and
• R18 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C10 carbocyclyl, or C6-C10 aryl;
• wherein the compound is not compound 12, compound 15, or any one of compounds 78-135 of Table 1,
• or a pharmaceutically acceptable salt thereof.